An optimized cytosine base editing system for Leishmania species improves editing efficiency, reduces toxicity, and ensures stable guide expression, enabling scalable loss-of-function screening and efficient creation of functional mutants.
Reduced parenteral glucose during neonatal infection redirects hepatic metabolism to oxidative phosphorylation and gluconeogenesis, dampens systemic proinflammatory responses, and significantly enhances survival in preterm newborns.
Ana Catarina Costa, Blanca R Murillo ... Monica M Sousa
Proteomic analyses reveal a distinct protein signature underlying microtubule organization and regenerative asymmetries in sensory neuron axons, supported by an in vitro system replicating key features of sensory neuron biology.
Cell biological approaches and spatiotemporally resolved proteome profiling demonstrate that the chemokine receptor CCR7 can activate G proteins after being internalized into endosomes, from where it regulates Rac1-dependent chemotaxis.
