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    1. Evolutionary Biology

    The evolutionary history of the ancient weevil family Belidae (Coleoptera: Curculionoidea) reveals the marks of Gondwana breakup and major floristic turnovers, including the rise of angiosperms

    Xuankun Li, Adriana E Marvaldi ... Duane D McKenna
    The evolutionary trajectory of phytophagous weevils reveals how ancient host plant shifts and continental drift influenced the development of diverse insect-plant interactions through time.
    1. Medicine

    Evaluation of clonal hematopoiesis and mosaic loss of Y chromosome in cardiovascular risk: An analysis in prospective studies

    Sami Fawaz, Severine Marti ... Thierry Couffinhal
    If CHIP and mLOY do not significantly contribute to inflammation, atherosclerosis or myocardial infarction risk independently, CHIP may increase the risk of MI in men who do not carry mLOY.
    1. Evolutionary Biology

    A systematic review and meta-analysis of eyespot anti-predator mechanisms

    Ayumi Mizuno, Malgorzata Lagisz ... Shinichi Nakagawa
    The efficacy of eyespots in deterring avian predators is more due to their conspicuousness rather than their resemblance to eyes.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    A multiplexed, single-cell sequencing screen identifies compounds that increase neurogenic reprogramming of murine Muller glia

    Amy Tresenrider, Marcus Hooper ... Thomas A Reh
    An in vitro chemical screen with single-cell sequencing output leads to the identification of Metformin as an in vivo enhancer of Muller glia to neuron reprogramming in mice.
    1. Neuroscience

    Beyond gradients: Factorized, geometric control of interference and generalization

    Daniel N Scott, Michael J Frank
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Cell Biology
    2. Neuroscience

    GEARBOCS: An Adeno Associated Virus Tool for In Vivo Gene Editing in Astrocytes

    Dhanesh Sivadasan Bindu, Justin T Savage ... Cagla Eroglu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Neuroscience

    Elucidating the Selection Mechanisms in Context-Dependent Computation through Low-Rank Neural Network Modeling

    Yiteng Zhang, Jianfeng Feng, Bin Min
    Not revised
    Reviewed Preprint v1
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    • Solid
    1. Cancer Biology
    2. Genetics and Genomics

    Recurrent disruption of tumour suppressor genes in cancer by somatic mutations in cleavage and polyadenylation signals

    Yaroslav Kainov, Fursham Hamid, Eugene V Makeyev
    Somatic mutations frequently disrupt cleavage and polyadenylation signals in tumour suppressor genes in human cancers, likely contributing to tumour progression.
    1. Ecology
    2. Microbiology and Infectious Disease

    Novel class IIb microcins show activity against Gram-negative ESKAPE and plant pathogens

    Benedikt M Mortzfeld, Shakti K Bhattarai, Vanni Bucci
    12 new class IIb microcins have been structurally identified, phylogenetically assessed, and functionally tested for their antimicrobial activity, increasing the total number of these bacteriocins to 17.
    Version of Record
    Short Report
    • Important
    • Solid