Marie-Cécile Dupas, Maria F Vincenti-Gonzalez ... Simon Dellicour
Post-2020, highly pathogenic avian influenza H5 circulation is characterised by spatially expanded ecological suitability, changes in key environmental predictors, and a wider range of avian species affected.
Bidirectional modulation of the activity of the synaptic protein mGluR5 alters spontaneous mouse motor behavior and produces correlated changes in co-activity patterns among direct pathway neurons in the dorsal striatum.
Durafshan Sakeena Syed, Primoz Ravbar, Julie H Simpson
Anatomical and behavioral characterization of inhibitory neurons in the Drosophila ventral nerve cord shows their critical, diverse roles in limb coordination.
A microglia replacement approach demonstrates that brain macrophages with patient mutations from Aicardi–Goutières syndrome, a genetic, brain predominant interferonopathy, are sufficient to drive interferon responses.
Developmental electrophysiological adaptations and heat-sensitive proteins, such as TRPV3, in cortical excitatory neurons help maintain stable activity levels when brain temperature rises by 2–3°C during fever.
Abdulkadir Ozkan, Hari K Padmanabhan ... Jeffrey D Macklis
Developmentally-based directed differentiation from cortical progenitors sets a foundation for in vitro mechanistic and therapeutic disease modeling, and toward regenerative neuronal repopulation and circuit repair.
Amanda L Hughes, Ramasubramanian Sundaramoorthy, Tom Owen-Hughes
Structures of the chromatin remodelling enzyme Chd1 during ongoing reactions reveal a reaction pathway tuned to generate nucleosome spacing similar to that observed in cells.
