Up-to-date computational pipeline characterizes G-protein-coupled receptor (GPCR) repertoires in the closest relatives of metazoans, providing a framework to investigate the evolutionary origins and ancestral functions of key metazoan signaling pathways.
Deletion of specific herpes simplex virus proteins prevents the progression of virus assembly at discrete stages, allowing detailed 3D imaging of rare events in the morphogenesis of virus particles.
Franka H van der Linden, Stephen C Thornquist ... Joachim Goedhart
Directed evolution was used to engineer a green fluorescent biosensor for quantitative calcium imaging that remains fluorescent, yet shows a large change in lifetime in cells.
Testosterone promotes the conversion of glucose to fatty acids by increasing the expression of ACLY in seminal vesicle epithelial cells, thereby regulating the seminal plasma components.
Loss of endothelial Slit2 removes the chemo-attractive signal needed for Robo1-positive sympathetic axons to follow coronary vessels, resulting in reduced ventricular innervation.
A vessel on a chip microfluidic device recapitulates the main features of meningococcal vascular colonization, providing high time and space microscopy resolution of the infection process in 3D.
Ripples maintain time-locked occurrence across the septo-temporal axis and hemispheres while showing local phase coupling, revealing a dual mode of synchrony in CA1 network dynamics.
