Foxp3 and Ikaros, two transcription factors genetically linked to autoimmune disease in humans, cooperate to establish the epigenomic and transcriptomic landscape of regulatory T cells.
Subtelomeric sequences in the yeast S. cerevisiae are dispensable for either cell proliferation or homologous recombination-mediated telomere maintenance in telomerase-null cells, suggesting that these sequences represent remnants of genome evolution.
Seemingly disparate working memory biases, including short-term serial and contraction biases, may arise from a common mechanism via the interaction of multiple networks, each operating over a distinct timescale.
The split mNeonGreen system enables fast and efficient endogenous tagging in human iPSCs and facilitates the study of proteins in human stem cells and differentiated cells by live imaging.
An unbiased approach unveils a non-canonical substrate of the known transporters, highlighting the mechanism behind the use of D-serine as a kidney biomarker.
A combination of patch clamp electrophysiology and FRET determine critical interactions between HCN4 channels and the ER resident protein LRMP and suggest a possible mechanism for reduced cAMP sensitivity.
Sensory hair cells in the inner ear use inhibitory G proteins with different regulators at different stages of development to break symmetry, adopt a proper orientation, and grow stereocilia.
