Purine recycling deficiency triggers metabolic and neurological defects reminiscent of Lesch–Nyhan disease in Drosophila, paving the way for studying this disorder and carrying out drug screening in an invertebrate organism.
Continuous noisy learning in neural networks leads to slow, directed qualitative changes in their internal representations, without affecting their quality.
Rita De Gasperi, Laszlo Csernoch ... Christopher P Cardozo
Genetic reduction of Numb or Numb/Nubl is linked to deterioration of the Septin cytoskeleton and suggests cytoskeletal abnormalities are the consequences of and contribute to age-related changes in skeletal muscle.
Marco van den Noort, Panagiotis Drougkas ... Bert Poolman
Transient and weak interactions between the substrate-binding proteins of the ATP-binding cassette transporter OpuA can influence the transport efficiency.
The N-terminal domain of Staphylococcus aureus GpsB, a scaffolding protein, forms an atypical asymmetric dimer and binds to the C-termini of FtsZ and PBP4, influencing the localization and regulation of both the Z-ring and cell wall synthesis.
Diversified genetic and transcriptional changes in parallel evolved Escherichia coli populations for improved growth revealed that the evolution complementing genome reduction was like all roads leading to Rome.
Local abnormal fungi in Caesarean section scar diverticulum can affect the abundance of bacteria through specific metabolites, thereby destroying the stability of bacteria and the entire microbial community.
