Laurie Peverini, Sophie Shi ... Pierre-Jean Corringer
Conformational motions elicited by antagonists, partial agonists, and agonists in serotonin-gated ion channels 5-HT3AR progressively spread from the extracellular to the transmembrane domain.
Yannick Schäfer, Katja Palitzsch ... Jaanus Suurväli
As a result of frequent gene duplication and haplotypic variation, a family of immune genes in the model vertebrate zebrafish has thousands of gene copies that are population- or individual-specific.
Elissavet Chartampila, Karim S Elayouby ... Helen E Scharfman
Supplementing the diet in early life with choline improved memory, neuronal morphology, and neuronal activity in mice with a genetic form of Alzheimer's disease, whereas low choline had mixed effects.
The parasitoid Trichopria drosophilae has evolved both molecular adaptions (venom proteins and teratocytes) and ecological strategies (tolerance of intraspecific and avoidance of interspecific competition) to successfully parasitize Drosophila suzukii.
Stephanie A Wankowicz, Ashraya Ravikumar ... James S Fraser
Creating structural models with multiple conformations of proteins improves the fit of the model to experimental data X-ray crystallography and improve the model geometry.
The 'low water' agar assay provides a reliable and practical high-throughput method for studying plant molecular signaling responses to drought stress.
The protein hyaluronan-mediated motility receptor interacts with microtubules to enhance their stability and recruits TPX2 to promote microtubule emanation in neurons.
Sanjay Kumar Sukumar, Vimala Antonydhason ... Ruth H Palmer
The newly characterized activity regulating neuropeptide encoding gene Spar is a transcriptional target of the Jeb/Alk receptor tyrosine kinase signaling pathway in the Drosophila nervous system.
Nguyen Lam Vuong, Nguyen Than Ha Quyen ... Ronald Geskus
Higher plasma viremia levels in early dengue and a slower subsequent decline are associated with worse clinical outcomes and provide valuable outcome measures for future therapeutic intervention trials.