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Page 378 of 1,750
    1. Cancer Biology
    2. Genetics and Genomics

    Multimodal analysis of methylomics and fragmentomics in plasma cell-free DNA for multi-cancer early detection and localization

    Van Thien Chi Nguyen, Trong Hieu Nguyen ... Le Son Tran
    SPOT-MAS (screening for the presence of tumor by methylation and size) is an affordable and effective multi-cancer early detection test analyzing multiple features of circulating tumor DNA.
    1. Neuroscience

    An observational treatment study of metacognition in anxious-depression

    Celine Ann Fox, Chi Tak Lee ... Claire M Gillan
    Improvement in levels of anxious-depression corresponds with increased confidence in performance among individuals receiving mental health treatment within a large longitudinal dataset.
    1. Biochemistry and Chemical Biology

    GDF15 is required for cold-induced thermogenesis and contributes to improved systemic metabolic health following loss of OPA1 in brown adipocytes

    Jayashree Jena, Luis Miguel García-Peña ... Renata O Pereira
    Deletion of optic atrophy 1 in brown adipose tissue induces secretion of growth differentiation factor 15 as a batokine to attenuate diet-induced obesity and improve glucose clearance, hepatic steatosis, and thermoregulation in mice by increasing energy expenditure.
    1. Cell Biology
    2. Neuroscience

    RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy

    Julie C Necarsulmer, Jeremy M Simon ... Todd J Cohen
    Impairing TDP-43 RNA-binding capacity through a single acetylation-mimic mutation alters TDP-43 function and recapitulates biochemical, molecular, and behavioral features of sporadic TDP-43 proteinopathies, thus providing opportunities for new research into pathogenic mechanisms and therapeutic interventions.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    PerTurboID, a targeted in situ method reveals the impact of kinase deletion on its local protein environment in the cytoadhesion complex of malaria-causing parasites

    Heledd Davies, Hugo Belda ... Moritz Treeck
    A new mass spectrometry-based method to identify and quantify changes in a subcellular local protein environment shows the impact of deletion of a kinase the human malaria parasites export into the host cell.
    1. Biochemistry and Chemical Biology
    2. Epidemiology and Global Health

    Status and physiological significance of circulating adiponectin in the very old and centenarians: an observational study

    Takashi Sasaki, Yoshinori Nishimoto ... Yasumichi Arai
    Circulating high-molecular-weight (cHMW) adiponectin levels increased with age until centenarians, and the contribution of known major factors associated with cHMW adiponectin levels including BMI varied with age, suggesting that its physiological significance also varies with age in the oldest old.
    1. Evolutionary Biology

    Selection and the direction of phenotypic evolution

    François Mallard, Bruno Afonso, Henrique Teotónio
    Predicting multivariate phenotypic evolution.
    1. Developmental Biology

    Scavenger receptor endocytosis controls apical membrane morphogenesis in the Drosophila airways

    Ana Sofia Pinheiro, Vasilios Tsarouhas ... Christos Samakovlis
    During tracheal morphogenesis, the scavenger receptor Emp senses and responds to luminal cargo levels by initiating apical membrane endocytosis along the longitudinal tube axis to restrict airway elongation.
    1. Neuroscience

    On the computational principles underlying human exploration

    Lior Fox, Ohad Dan, Yonatan Loewenstein
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Genetics and Genomics
    2. Neuroscience

    Tyramine and its Amtyr1 receptor modulate attention in honey bees (Apis mellifera)

    Joseph S Latshaw, Reece E Mazade ... Brian Smith
    Genetic variation in a biogenic amines receptor underlies a means of gain control for nonassociative learning and hence an important form of attention that is the basis for tradeoffs in foraging in a social collective.