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    1. Neuroscience

    Optogenetic induction of appetitive and aversive taste memories in Drosophila

    Meghan Jelen, Pierre-Yves Musso ... Michael D Gordon
    Closed-loop pairing of taste stimuli with optogenetic activation of neurons encoding either reward or punishment reveals that flies can form both appetitive and aversive taste memories that impact their future behavioral responses to tastes.
    1. Genetics and Genomics
    2. Computational and Systems Biology

    Novel discoveries and enhanced genomic prediction from modelling genetic risk of cancer age-at-onset

    Ekaterina S. Maksimova, Sven E. Ojavee ... Matthew R. Robinson
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Ecology
    2. Evolutionary Biology

    Response to comment on 'Parasite defensive limb movements enhance acoustic signal attraction in male little torrent frogs'

    Longhui Zhao, Wouter Halfwerk, Jianguo Cui
    We are writing to respond to the comment by Anderson et al., 2023 on our article about limb movements in male little torrent frogs (Zhao et al., 2022).
    1. Ecology
    2. Evolutionary Biology

    Comment on 'Parasite defensive limb movements enhance acoustic signal attraction in male little torrent frogs'

    Nigel K Anderson, Doris Preininger, Matthew J Fuxjager
    We are writing to comment on the article by Zhao et al., 2023 about limb movements in male little torrent frogs.
    1. Medicine

    SIRT2 inhibition protects against cardiac hypertrophy and ischemic injury

    Xiaoyan Yang, Hsiang-Chun Chang ... Hossein Ardehali
    SIRT2 has detrimental effects in the heart and plays a role in cardiac response to injury and the progression of cardiac hypertrophy, and targeting SIRT2 may provide a novel avenue for the treatment of cardiac hypertrophy and ischemic disease.
    1. Cancer Biology

    Post-EMT: Cadherin-11 mediates cancer hijacking fibroblasts

    Weirong Kang, Yibo Fan ... Zhizhan Gu
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Incomplete
    1. Neuroscience

    Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming

    Jie Yang, Ruijun Tang ... Liming Wang
    Exposure to high-sugar diet in Drosophila resulted in the suppression of sweet sensitivity and feeding behavior in the offspring via altered epigenetic modifications on the histone, highlighting sustained impact of ancestral experience on the physiology and health of offspring.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Diminishing neuronal acidification by channelrhodopsins with low proton conduction

    Rebecca Frank Hayward, F Phil Brooks III ... Adam E Cohen
    Many channelrhodopsins acidify cells, but two new ones do not.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dissecting the phase separation and oligomerization activities of the carboxysome positioning protein McdB

    Joseph L Basalla, Claudia A Mak ... Anthony G Vecchiarelli
    Carbon-fixing organelles, called carboxysomes, link to their spatial organization system in the bacterial cell by a hexameric protein that forms pH-dependent condensates via a nuanced multidomain mechanism.
    1. Cell Biology

    Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI

    Alexander Kapustin, Sofia Serena Tsakali ... Catherine M Shanahan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete