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    1. Neuroscience

    Exposure to high-sugar diet induces transgenerational changes in sweet sensitivity and feeding behavior via H3K27me3 reprogramming

    Jie Yang, Ruijun Tang ... Liming Wang
    Exposure to high-sugar diet in Drosophila resulted in the suppression of sweet sensitivity and feeding behavior in the offspring via altered epigenetic modifications on the histone, highlighting sustained impact of ancestral experience on the physiology and health of offspring.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Diminishing neuronal acidification by channelrhodopsins with low proton conduction

    Rebecca Frank Hayward, F Phil Brooks III ... Adam E Cohen
    Many channelrhodopsins acidify cells, but two new ones do not.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Dissecting the phase separation and oligomerization activities of the carboxysome positioning protein McdB

    Joseph L Basalla, Claudia A Mak ... Anthony G Vecchiarelli
    Carbon-fixing organelles, called carboxysomes, link to their spatial organization system in the bacterial cell by a hexameric protein that forms pH-dependent condensates via a nuanced multidomain mechanism.
    1. Cell Biology

    Extracellular vesicles stimulate smooth muscle cell migration by presenting collagen VI

    Alexander Kapustin, Sofia Serena Tsakali ... Catherine M Shanahan
    Not revised
    Reviewed Preprint v1
    • Useful
    • Incomplete
    1. Structural Biology and Molecular Biophysics

    Allosteric inhibition of the T cell receptor by a designed membrane ligand

    Yujie Ye, Shumpei Morita ... Francisco N Barrera
    A designer peptide inhibits the T cell receptor through allosteric binding to the transmembrane region.
    1. Structural Biology and Molecular Biophysics

    Absence of electron-transfer-associated changes in the time-dependent X-ray free-electron laser structures of the photosynthetic reaction center

    Gai Nishikawa, Yu Sugo ... Hiroshi Ishikita
    Revisiting limitations in time-resolved X-ray free-electron laser structures of the bacterial photosynthetic reaction center uncovers their irrelevance to proposed structural changes in electron transfer dynamics.
    1. Neuroscience

    Thalamic regulation of ocular dominance plasticity in adult visual cortex

    Yi Qin, Mehran Ahmadlou ... Christiaan N Levelt
    Inhibitory innervation in the dorsolateral geniculate nucleus is crucial for adult thalamic and cortical ocular dominance plasticity, highlighting potential thalamic involvement in conditions like amblyopia and learning disabilities.
    1. Cell Biology

    Atypical peripheral actin band formation via overactivation of RhoA and nonmuscle myosin II in mitofusin 2-deficient cells

    Yueyang Wang, Lee D Troughton ... Qing Deng
    Mfn2 depletion upregulates cytosolic Ca2+ in mouse fibroblast cells, leading to RhoA and nonmuscle myosin II overactivation and a prominent peripheral actin band structure, which is dependent on the contractile force on the cell–substrate interface.
    1. Neuroscience

    Atypical cognitive training-induced learning and brain plasticity and their relation to insistence on sameness in children with autism

    Jin Liu, Hyesang Chang ... Vinod Menon
    Learning in children with autism spectrum disorder (ASD) was achieved by fundamentally different cognitive and neural mechanisms from typically developing children, and insistence on sameness, a core symptom of ASD, contributed to such atypical mechanisms of learning in affected children.
    1. Neuroscience

    A theory of hippocampal theta correlations accounting for extrinsic and intrinsic sequences

    Yuk-Hoi Yiu, Christian Leibold
    A spiking neural network model explains how hippocampal theta sequences in two-dimensional arenas can arise from a combination of sensory-motor inputs, short-term synaptic plasticity, and intrinsic connectivity.