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Page 391 of 1,810
    1. Neuroscience

    Rabies virus-based barcoded neuroanatomy resolved by single-cell RNA and in situ sequencing

    Aixin Zhang, Lei Jin ... Xiaoyin Chen
    Barcoded rabies virus tracing combined with single-cell RNAseq and in situ sequencing achieves high-throughput retrograde projection mapping and synaptic connectivity mapping at cellular resolution.
    1. Medicine
    2. Neuroscience

    Depletion of SMN protein in mesenchymal progenitors impairs the development of bone and neuromuscular junction in spinal muscular atrophy

    Sang-Hyeon Hann, Seon-Yong Kim ... Young-Yun Kong
    Fibro-adipogenic progenitors in skeletal muscle contribute to the neuromuscular pathogenesis of spinal muscular atrophy, and depletion of SMN in chondrocytes reduces local IGF sigaling in growth plate.
    1. Epidemiology and Global Health
    2. Medicine

    Primaquine in glucose-6-phosphate dehydrogenase deficiency: an adaptive pharmacometric assessment of ascending dose regimens in healthy volunteers

    Sasithon Pukrittayakamee, Podjanee Jittamala ... Nicholas J White
    A full radical curative dose of primaquine can be given to fully glucose-6-phosphate dehydrogenase-deficient males safely using an ascending dose regimen.
    1. Immunology and Inflammation
    2. Medicine

    β-Carotene accelerates the resolution of atherosclerosis in mice

    Ivan Pinos, Johana Coronel ... Jaume Amengual
    Vitamin A formation from β-carotene promotes an anti-inflammatory environment and remodeling of atherosclerotic lesions during the healing of atherosclerosis.
    1. Neuroscience

    A prefrontal network model operating near steady and oscillatory states links spike desynchronization and synaptic deficits in schizophrenia

    David A Crowe, Andrew Willow ... Bagrat Amirikian
    Cortical network model suggests a mechanism explaining the link between NMDAR synaptic and spike synchrony deficits observed in a pharmacological monkey model of prefrontal network failure in schizophrenia.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Activity of MukBEF for chromosome management in E. coli and its inhibition by MatP

    Mohammed Seba, Frederic Boccard, Stéphane Duigou
    MukBEF selectively loads onto newly replicated DNA, and MatP prevents MukBEF activity, correlating with matS sites, likely due to MatP-mediated unloading.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Identification of 1600 replication origins in S. cerevisiae

    Eric J Foss, Carmina Lichauco ... Antonio Bedalov
    Replication origins in yeast are more widespread than previously believed.
    1. Developmental Biology

    Rtf1-dependent transcriptional pausing regulates cardiogenesis

    Adam D. Langenbacher, Fei Lu ... Jau-Nian Chen
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Stem Cells and Regenerative Medicine

    Computationally defined and in vitro validated putative genomic safe harbour loci for transgene expression in human cells

    Matias I Autio, Efthymios Motakis ... Roger SY Foo
    Depiction of novel human genomic safe harbour loci that have been validated in vitro for safety and stable expression in human embryonic stem cells and cell types from all the three germ lineages.
    1. Developmental Biology
    2. Physics of Living Systems

    Core PCP mutations affect short-time mechanical properties but not tissue morphogenesis in the Drosophila pupal wing

    Romina Piscitello-Gómez, Franz S Gruber ... Suzanne Eaton
    Quantitative analysis of cell dynamics over a range of timescales reveals that core PCP is not required to organize large-scale tissue flows but does affect short timescale mechanics.