The target-myristoyl switch induced by protein-protein interaction is a novel regulatory mechanism for myristoylated EF-hand calcium-binding proteins, in which target binding facilitates exposure of the myristoyl anchor and the association to the lipid membrane in a calcium-independent manner.
James M Roe, Didac Vidal-Pineiro ... René Westerhausen
Brain asymmetry in cortical surface area shows lifespan stability from early childhood to old age and is more underpinned by genetic differences, whereas asymmetry in cortical thickness grows through childhood and adolescence and is minimally explained by genetics.
Decline in cervical cancer screening and challenges faced by healthcare professionals and patients when the pandemic was declared emphasize the importance of implementing human papillomavirus (HPV) primary screening, HPV self-sampling, and telemedicine to continue cervical cancer screening and care.
An experimental and computational system has been developed to investigate how wavelike gene expression patterns are generated during embryonic development.
Neuropeptide Y-expressing interneurons in the spinal dorsal horn have a broad inhibitory role, suppressing pruritogen-evoked itch and reducing behavioural signs of acute, inflammatory, and neuropathic pain.
Imke Ensinck, Alexander Maman ... Folkert J van Werven
The N6-methyladenosine (m6A) methyltransferase complex in budding yeast is highly conserved, yet reconfigured with respect to its mammalian counterpart and has both m6A-dependent and m6A-independent functions.
Melanocortin 1 receptor (MC1-R) deficiency in hepatocytes increases cholesterol levels in the circulation and liver in mice, while selective activation of MC1-R reduces cellular cholesterol content in cultured hepatocytes.
A genetic screen identifies a lipid pathway which impacts the endoplasmic reticulum unfolded protein response and highlights a mechanism through which lipid disequilibrium might facilitate the progression of proteopathic diseases.
The dorsal telencephalon (pallium) in medaka fish accommodates an epigenetically distinct brain area that selectively regulates unique set of synaptic genes compared to the surrounding pallial region, providing insights into the evolution of the pallium in vertebrate.
