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Page 411 of 1,753
    1. Neuroscience

    Theta-phase-specific modulation of dentate gyrus memory neurons

    Bahar Rahsepar, Jacob F Norman ... John A White
    Consistent with an existing computational model of hippocampal function, using real-time feedback to drive artificial memories at the trough of the hippocampal theta rhythm improves apparent recall.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Phosphorylation of tyrosine 90 in SH3 domain is a new regulatory switch controlling Src kinase

    Lenka Koudelková, Markéta Pelantová ... Daniel Rösel
    The functional role of novel regulatory mechanism within prototypic oncogenic kinase c-Src is described with particular emphasis on cancer cell migration, invasiveness, oncogenic transformation, and multilevel regulation of Src itself.
    1. Neuroscience

    Recapitulation of pathophysiological features of AD in SARS-CoV-2-infected subjects

    Elizabeth Griggs, Kyle Trageser ... Giulio Maria Pasinetti
    New evidence of brain proinflammatory cascades supports post-acute sequelae of SARS-CoV-2 infection, ultimately promoting the onset and progression of Alzheimer's disease as a function of age.
    1. Computational and Systems Biology
    2. Neuroscience

    Contrasting action and posture coding with hierarchical deep neural network models of proprioception

    Kai J Sandbrink, Pranav Mamidanna ... Alexander Mathis
    To isolate and study proprioception, hierarchical deep neural networks paired with biomechanical models provide a normative approach to test the role of task effects on neural representations, such as the emergence of kinematic tuning and higher-level abstractions of actions.
    1. Physics of Living Systems

    Fluid extraction from the left-right organizer uncovers mechanical properties needed for symmetry breaking

    Pedro Sampaio, Sara Pestana ... Susana Santos Lopes
    Zebrafish have a physiological time-window of 1 hr for breaking left-right symmetry and are highly sensitive to the left-right organizer anterior fluid mechanics rather than to the nature of its fluid content.
    1. Cell Biology

    The yeast endocytic early/sorting compartment exists as an independent sub-compartment within the trans-Golgi network

    Junko Y Toshima, Ayana Tsukahara ... Jiro Toshima
    The yeast syntaxin homolog Tlg2p-residing sub-compartment within the trans-Golgi network is the primary endocytic-accepting region that serves as an early/sorting compartment.
    1. Immunology and Inflammation

    The role of B cells in immune cell activation in polycystic ovary syndrome

    Angelo Ascani, Sara Torstensson ... Elisabet Stener-Victorin
    Androgen receptor activation modifies B cell frequencies and functionality, accompanied by weight gain in female mice exposed to human PCOS IgG, highlighting the unrecognized involvement of B cells in PCOS autoimmune comorbidities despite their absence not preventing PCOS phenotype development.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Association of close-range contact patterns with SARS-CoV-2: a household transmission study

    Jackie Kleynhans, Lorenzo Dall'Amico ... SA-S-HTS Group
    While recognizing study design limitations, the lack of association between household close range proximity events and SARS-CoV-2 transmission, suggests that aerosol transmission may play a larger role than droplet transmission in the household.
    1. Microbiology and Infectious Disease

    A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection

    Jessie Kulsuptrakul, Elizabeth A Turcotte ... Patrick S Mitchell
    HIV-1 infection activates the human CARD8 inflammasome via innate immune recognition of HIV-1 viral protease activity.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A critical evaluation of protein kinase regulation by activation loop autophosphorylation

    Ronja Reinhardt, Thomas A Leonard
    Understanding protein kinase regulation by activation loop autophosphorylation depends on a critical assessment of experimental design, execution, and interpretation.