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Using state-specific contacts inferred from coevolving residue pairs enables us to build models of the various conformational states along the sugar porter functional cycle and reconstruct the free-energy landscape of the process.

A laboratory experiment provides the first evidence that framing a sham treatment as personalised to one's genetics and physiology increases its placebo effect on pain.

Computational approach shows that the occluded state in GLUT transporters is equivalent to the transition state of soluble enzymes and this has the highest affinity for the substrate sugar.

Type IV collagen plays a dual role in both structurally fastening tissues and signaling through the discoidin domain receptor 2 to synchronize an integrin adhesion that stabilizes tissue linkage.

Biallelic MAD2L1BP variants contribute to oocyte metaphase I arrest in women with primary infertility and p31^comet is required for human oocyte maturation.

Live-cell single-molecule imaging of DNA repair factors can be used to analyze their localization to DNA lesions and dissect the hierarchy of their recruitment.

Ketamine induces the expression of Ca²⁺-permeable AMPA receptors to enhance synaptic glutamatergic and Ca²⁺ activity in neurons to cause rapid antidepressant effects.

A single-cell gene expression atlas in a human parasitic nematode provides new insights into the distribution of anthelmintic targets and the origins of secretory molecules with diagnostic and therapeutic potential at the host–parasite interface.

The complex histories of social relationships between enslaved and non-enslaved communities and their descendants during and after the Trans-Atlantic Slave-Trade shaped the detailed genetic and linguistic histories of admixture of the islands of Cabo Verde.