Browse our latest research

Page 441 of 1,750
    1. Microbiology and Infectious Disease

    A frameshift in Yersinia pestis rcsD alters canonical Rcs signalling to preserve flea-mammal plague transmission cycles

    Xiao-Peng Guo, Hai-Qin Yan ... Yi-Cheng Sun
    Pseudogenization of rcsD alters canonical Rcs phosphorelay signalling and marks a significant adaptive evolutionary step in the emergence of ubiquitous extant branches of Yersinia pestis that can maintain stable plague outbreaks.
    1. Cell Biology
    2. Genetics and Genomics

    The nutrient-sensing GCN2 signaling pathway is essential for circadian clock function by regulating histone acetylation under amino acid starvation

    Xiao-Lan Liu, Yulin Yang ... Xiao Liu
    The nutrient-sensing GCN2 signaling pathway is required for robust circadian rhythm by recruiting the histone acetyltransferase GCN5 to establish a proper chromatin state at the circadian clock gene promoter under amino acid starvation in Neurospora.
    1. Ecology
    2. Evolutionary Biology

    Thermal phenotypic plasticity of pre- and post-copulatory male harm buffers sexual conflict in wild Drosophila melanogaster

    Claudia Londoño-Nieto, Roberto García-Roa ... Pau Carazo
    Natural temperature variation across an optimal reproductive range for wild flies (Drosophila melanogaster) modulates the impact of sexual conflict on female fitness via asymmetric effects on pre- and post-copulatory male harm mechanisms.
    1. Neuroscience

    Cerebellar Activation Bidirectionally Regulates Nucleus Accumbens Core and Medial Shell

    Alexa F. D’Ambra, Ksenia Vlasov ... Diasynou Fioravante
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Immunology and Inflammation

    Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis

    Zihao Yao, Weizhong Qi ... Haiyan Zhang
    Down-regulation of GAS6 by M1 macrophages resulted in impaired efferocytosis for synovial apoptotic cells, causing synovial hyperplasia and obesity-associated OA development.
    1. Cancer Biology
    2. Cell Biology

    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    ERK3 controls actin cytoskeleton.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The mutational signatures of poor treatment outcomes on the drug-susceptible Mycobacterium tuberculosis genome

    Yiwang Chen, Qi Jiang ... Qian Gao
    There are fourteen genomic variants of Mycobacterium tuberculosis that are significantly associated with poor treatment outcomes in drug-susceptible TB patients, but their predictive value is limited.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function

    Tal Ben Yaakov, Tanya Wasserman ... Yonatan Savir
    The ovarian immune system ages while coping with the two main challenges of the aging ovary before menopause, the inflammatory stimulations due to repeated cycles and the increasing need for clearance of accumulating atretic follicles.
    1. Ecology
    2. Evolutionary Biology

    Sensory conflict disrupts circadian rhythms in the sea anemone Nematostella vectensis

    Cory A Berger, Ann M Tarrant
    Misalignment between light and temperature cycles leads to disrupted circadian behavior and a substantially altered rhythmic transcriptome.
    1. Neuroscience

    Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS

    Janani Parameswaran, Nancy Zhang ... Jie Jiang
    C9ORF72 antisense repeat expanded RNAs activate PKR/eIF2α dependent integrated stress response and cause neuronal toxicity independent of DPR proteins.