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Page 440 of 1,750
    1. Neuroscience

    Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate

    Adam R Almeida, Wendy B Macklin
    Oligodendrocytes iteratively wrap and unwrap the same domain of an axon multiple times during development, which likely impacts myelin sheath stabilization.
    1. Computational and Systems Biology
    2. Developmental Biology

    Dynamic fibronectin assembly and remodeling by leader neural crest cells prevents jamming in collective cell migration

    William Duncan Martinson, Rebecca McLennan ... Philip K Maini
    Data-driven mathematical modeling suggests that leading neural crest cells in a moving stream can robustly communicate with trailing cells by remodeling their extracellular matrix, thereby enabling long-distance collective migration.
    1. Epidemiology and Global Health

    Environment- and epigenome-wide association study of obesity in ‘Children of 1997’ birth cohort

    Jie Zhao, Bohan Fan ... C Mary Schooling
    The comprehensive assessment on environmental factors and epigenetics with obesity provides novel insights into potentially modifiable factors related to obesity at the outset and the end of puberty, with close relevance to health policy and public health.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Coevolutionary dynamics via adaptive feedback in collective-risk social dilemma game

    Linjie Liu, Xiaojie Chen, Attila Szolnoki
    The two-way coupling between collective actions and risk is essential to avoid the tragedy of the commons.
    1. Developmental Biology
    2. Neuroscience

    Origin of wiring specificity in an olfactory map revealed by neuron type–specific, time-lapse imaging of dendrite targeting

    Kenneth Kin Lam Wong, Tongchao Li ... Liqun Luo
    Advanced genetics and imaging reveal wiring logic underlying the olfactory map organization in the developing fruit fly brain, and strategies employed by projection neurons to target dendrites to specific locations in a timely manner.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Formation and three-dimensional architecture of Leishmania adhesion in the sand fly vector

    Ryuji Yanase, Flávia Moreira-Leite ... Jack D Sunter
    Using advanced volume electron microscopy, the ultrastructural and spatial organisation of Leishmania parasites strongly adhered to the gut of its sand fly vector was defined.
    1. Developmental Biology
    2. Immunology and Inflammation

    Human DUX4 and mouse Dux interact with STAT1 and broadly inhibit interferon-stimulated gene induction

    Amy E Spens, Nicholas A Sutliff ... Stephen J Tapscott
    The developmental transcription factor DUX4 interacts with STAT1 and broadly suppresses expression of IFNγ-stimulated genes.
    1. Plant Biology

    Effector target-guided engineering of an integrated domain expands the disease resistance profile of a rice NLR immune receptor

    Josephine HR Maidment, Motoki Shimizu ... Mark J Banfield
    Effector target-guided engineering has developed plant NLR immune receptors that bind and recognize stealthy pathogen effector proteins, demonstrating new disease resistance profiles in planta, and offering a promising approach to protect crops against plant pathogens.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Cannabidiol sensitizes TRPV2 channels to activation by 2-APB

    Aaron Gochman, Xiao-Feng Tan ... Andres Jara-Oseguera
    Cannabidiol is an ultra potent sensitizer for 2-APB responses in rTRPV2 and mTRPV3 channels but not in rTRPV1 through a mechanism that engages channel regions further from the cannabidiol binding site and the pore.
    1. Cell Biology
    2. Computational and Systems Biology

    Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response

    Rania Garde, Abhyudai Singh ... David Pincus
    The chaperones Hsp70 and Sis1 collaborate to repress the heat shock response and are both transcriptional targets of the heat shock response, yet only Hsp70 acts as a negative feedback regulator of the heat shock response.