Hiroaki Eshima, Justin L Shahtout ... Katsuhiko Funai
Genetic or pharmacological suppression of lipid peroxidation pathway protects skeletal muscle from disuse-induced atrophy and weakness in young and old mice.
Krithika Venkataraman, Nadav Shai ... Leslie B Vosshall
Two novel, tightly linked, and rapidly evolving genes encoding small secreted proteins are necessary for female mosquitoes to protect their retained eggs during extended periods of drought.
A model of hippocampal replay is proposed that gives a biologically plausible account of how the hippocampus could prioritize replay and produce a variety of different replay statistics, and is efficient in driving spatial learning.
NFATc1 is identified as a molecular marker of articular cartilage progenitor cells and a transcriptional repressor of chondrocyte differentiation, providing fundamental insights into the origin and differentiation mechanism of articular chondrocytes.
Xinzhu Wei, Christopher R Robles ... Sriram Sankararaman
Genetic variants introgressed into modern humans from Neanderthals tend to be depleted in their contribution to heritable trait variation relative to modern human variants consistent with the action of purifying selection.
Regulatory hierarchies controlling sex determination and X-chromosome dosage compensation between closely-related nematode species are conserved, but X-chromosome target specificity for the condensin dosage compensation complex has diverged, thereby contributing to reproductive isolation.
Elimination of extreme reporters using Goldberg cutoffs does not always produce unbiased estimates of associations between nutrition intakes and health outcomes.
Monica Sanchez-Contreras, Mariya T Sweetwyne ... Scott R Kennedy
The accumulation of somatic mutations during aging is not uniform across tissue types and, in addition, shows significant variability in the source of mutation that can be modified by small molecule interventions.
Amichai Baichman-Kass, Tingting Song, Jonathan Friedman
High-throughput measurements of simplified bacterial communities find that when multiple species jointly inhibit a focal species of interest, their individual effects do not add up, but are dominated by the strongest single-species effect.
