Browse our latest research

Page 471 of 1,762
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Nuclear m6A reader YTHDC1 promotes muscle stem cell activation/proliferation by regulating mRNA splicing and nuclear export

    Yulong Qiao, Qiang Sun ... Huating Wang
    YTHDC1 is an essential factor controlling satellite cell regenerative ability through multifaceted gene regulatory mechanisms in myoblast cells.
    1. Neuroscience

    Firing patterns of ventral hippocampal neurons predict the exploration of anxiogenic locations

    Hugo Malagon-Vina, Stéphane Ciocchi, Thomas Klausberger
    A novel behavioural paradigm reveals how neurons in the ventral hippocampus dynamically adapt their firing activity after the introduction of an anxiogenic location.
    1. Neuroscience

    Retinal microvascular and neuronal pathologies probed in vivo by adaptive optical two-photon fluorescence microscopy

    Qinrong Zhang, Yuhan Yang ... Na Ji
    A properly designed two-photon fluorescence microscope allows high-resolution visualization of neurons and capillaries in healthy and diseased mouse retinas in vivo, while to visualize subcellular structures, adaptive optics is required to correct the eye-induced optical aberrations.
    1. Developmental Biology
    2. Genetics and Genomics

    Evidence for RNA or protein transport from somatic tissues to the male reproductive tract in mouse

    Vera Rinaldi, Kathleen Messemer ... Oliver J Rando
    Tissue-specific Cre recombinase often drives 'off-target' reporter activity in the male reproductive tract, suggesting the potential for inter-tissue RNA or protein trafficking in control of sperm maturation or other aspects of reproductive physiology.
    1. Developmental Biology

    Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis

    Jeff Jiajing Zhou, Jin Sun Cho ... Ken WY Cho
    Histone deacetylase 1 (Hdac1) plays a crucial role in maintaining differential histone acetylation states of enhancers in various germ layers and regulates the transcriptional program both temporally and spatially.
    1. Genetics and Genomics
    2. Medicine

    Phenome-wide Mendelian randomization study of plasma triglyceride levels and 2600 disease traits

    Joshua K Park, Shantanu Bafna ... Ron Do
    Phenome-wide estimation of causality between plasma triglyceride levels and disease risk highlights associations with atherosclerotic disease and other unrelated diseases.
    1. Epidemiology and Global Health

    Weakening of the cognition and height association from 1957 to 2018: Findings from four British birth cohort studies

    David Bann, Liam Wright ... Vanessa Moulton
    The link between height and cognitive assessment scores substantially weakened from 1957 to 2018.
    1. Neuroscience

    The rostral intralaminar nuclear complex of the thalamus supports striatally mediated action reinforcement

    Kara K Cover, Abby G Lieberman ... Brian N Mathur
    Neural circuit monitoring and manipulation reveal that neurons of the rostral intralaminar nuclei of the thalamus projecting to the dorsal striatum activate at movement initiation and reward to reinforce actions.
    1. Epidemiology and Global Health

    A modelled evaluation of the impact of COVID-19 on breast, bowel, and cervical cancer screening programmes in Australia

    Carolyn Nickson, Megan A Smith ... Karen Canfell
    Modelled estimates for changes in cancer incidence, staging, and demand on health services are presented for a range of potential COVID-related disruptions to national population screening programmes for breast, cervical, and colorectal cancer, indicating markedly different impacts for each programme.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Competition between lysogenic and sensitive bacteria is determined by the fitness costs of the different emerging phage-resistance strategies

    Olaya Rendueles, Jorge AM de Sousa, Eduardo PC Rocha
    The emergence and evolution of different phage-resistance strategies during coevolution between a phage-sensitive strain and a polylysogenic competitor depend on the amount of phage pressure, the fitness costs of resistance, and how these may change at different time scales.