Browse our latest research

Page 473 of 1,762
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Aggregating in vitro-grown adipocytes to produce macroscale cell-cultured fat tissue with tunable lipid compositions for food applications

    John Se Kit Yuen Jr, Michael K Saad ... David L Kaplan
    A simple way to create larger volumes of fat tissue for food purposes may be to grow individual fat cells and mechanically combine them together (rather than directly growing the full tissue).
    1. Cell Biology
    2. Cancer Biology

    Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion

    Elena Tomas Bort, Megan D Joseph ... Richard P Grose
    New role of P2Y2-αV integrin interactions in ATP-driven pancreatic cancer cell invasion provides a potential anti-metastatic target for pancreatic cancer.
    1. Neuroscience

    The cellular architecture of memory modules in Drosophila supports stochastic input integration

    Omar A Hafez, Benjamin Escribano ... Jan Pielage
    Computational modeling of a central decision neuron of Drosophila reveals an electrotonically compact architecture that is ideally suited to support efficient memory storage within a stochastically connected memory circuit.
    1. Neuroscience

    Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex

    Joaquin Gonzalez, Pablo Torterolo, Adriano BL Tort
    Computational analyses of in-vivo cerebral activity show that gamma oscillations in the olfactory cortex originate from local feedback inhibition following each sniff and serve to segregate competing odor representations through a winner-take-all process, providing an optimal window to decode odor.
    1. Computational and Systems Biology
    2. Medicine

    Development and evaluation of a live birth prediction model for evaluating human blastocysts from a retrospective study

    Hang Liu, Zhuoran Zhang ... Yu Sun
    The inclusion of the patient couple's clinical features along with blastocyst images increases live birth prediction accuracy.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Ablation of palladin in adult heart causes dilated cardiomyopathy associated with intercalated disc abnormalities

    Giuseppina Mastrototaro, Pierluigi Carullo ... Marie-Louise Bang
    FHOD1 and CARP/Ankrd1 interact with the N-terminal region of palladin and cardiomyocyte-specific deletion of palladin in adult, but not embryonic, mice leads to dilated cardiomyopathy associated with intercalated disc widening.
    1. Plant Biology

    Computational modeling of cambium activity provides a regulatory framework for simulating radial plant growth

    Ivan Lebovka, Bruno Hay Mele ... Thomas Greb
    Radial plant growth produces large parts of terrestrial biomass and can be computationally simulated with the help of an instructive framework of intercellular communication loops.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Lineage-specific differences and regulatory networks governing human chondrocyte development

    Daniel Richard, Steven Pregizer ... April M Craft
    The transcriptomic and epigenetic landscapes of developing human articular and growth plate cartilage reveal putative gene regulatory networks governing lineage commitment and tissue homeostasis.
    1. Neuroscience

    Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases

    Eleftheria Koropouli, Qiang Wang ... Alex L Kolodkin
    Posttranslational protein palmitoylation and palmitoyl acyltransferase-substrate specificity emerge as a novel mechanism specifying the functional identity of neuronal substrates during the development of the central nervous system.
    1. Immunology and Inflammation

    PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

    Warren Anderson, Fariba Barahmand-pour-Whitman ... David J Rawlings
    Gene editing to generate precisely matched primary human T cell populations demonstrates that the common autoimmune risk allele in the tyrosine phosphatase, PTPN22, promotes signaling in cells expressing a low-avidity, self-reactive TCR specific for a diabetes-associated self-antigen.