Hidehiko Okuma, Jeffrey M Hord ... Kevin P Campbell
N-terminal domain of dystroglycan enables like-acetylglucosaminyl transferase to elongate matriglycan on α-dystroglycan and prevent skeletal muscle pathophysiology.
Genome editing to insert a light-sensitive dimerization module directly into the EB1 microtubule plus end adaptor gene in human induced pluripotent stem cells enables local and acute optogenetic EB1 inactivation highlighting microtubule functions in developing neuronal growth cones.
A new multi camera imaging platform simultaneously captures large-area, high-resolution video of unconstrained small model organisms and provides behavioral measurements that span multiple spatial scales.
Evgeniya N Andreyeva, Alexander V Emelyanov ... Dmitry V Fyodorov
Biochemical and biological characterization of insulator complex SUMM4 reveals that, in addition to disrupting enhancer–promoter interactions and establishing chromatin barriers, it functions to delay DNA replication, thus implicating architectural proteins in shaping spatiotemporal patterns of replication.
Ching-Ho Chang, Isabel Mejia Natividad, Harmit S Malik
Genetic conflicts between sex chromosomes during spermatogenesis may drive the rapid evolution, function, and turnover of some sperm nuclear basic proteins in Drosophila species.
Evelyn Jagoda, Davide Marnetto ... Terence D Capellini
Key functional variants, discovered using Massively Parallel Reporter Assay (MPRA) and reporter assays in the context of SARS-CoV-2 infection, support the importance of two critical chemokine receptor genes CCR1 and CCR5 in severe Covid-19 illness.
The conformational switch of ABCG2 from the high substrate affinity inward-facing to a low substrate affinity outward-facing state is induced by nucleotide binding and accelerated by transported substrates.
Nadescha Trudel, Patricia L Lockwood ... Marco K Wittmann
People's confidence in information and their neural correlates in key regions of the social brain are more stable when tracking social advice compared to non-social information.
Having the eye open under the patch, even though this does not change the exogenous stimulation because the eye is occluded, will result in an enhanced short-term effect for ocular dominance due to the internal neural states.
