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    1. Structural Biology and Molecular Biophysics

    The SARS-CoV-2 accessory protein Orf3a is not an ion channel, but does interact with trafficking proteins

    Alexandria N Miller, Patrick R Houlihan ... David E Clapham
    SARS coronaviruses encode several mysterious proteins such as Orf3a and, in contrast to what has been claimed, Orf3a is not an ion channel but rather disrupts cellular trafficking by binding to the protein sorting complex known as HOPS.
    1. Cell Biology
    2. Immunology and Inflammation

    Transiently heritable fates and quorum sensing drive early IFN-I response dynamics

    Laura C Van Eyndhoven, Vincent PG Verberne ... Jurjen Tel
    Early IFN-I response dynamics are initiated in only fractions of cells, of which their epigenetic profile is transiently heritable and subject to the effects of quorum sensing.
    1. Developmental Biology
    2. Neuroscience

    Coordinated cadherin functions sculpt respiratory motor circuit connectivity

    Alicia N Vagnozzi, Matthew T Moore ... Polyxeni Philippidou
    A complementary cadherin code is required in phrenic motor neurons and respiratory interneurons to generate robust breathing motor output.
    1. Neuroscience

    Sensorimotor feedback loops are selectively sensitive to reward

    Olivier Codol, Mehrdad Kashefi ... Paul L Gribble
    Motor performance benefits from rewarding contexts via a non-uniform reduction of response latencies and increase in feedback gains across the feedback loops involved in upper limb motor control.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    The forgotten people: Hepatitis B virus (HBV) infection as a priority for the inclusion health agenda

    Emily Martyn, Sarah Eisen ... Philippa C Matthews
    Hepatitis B virus infection is a neglected challenge among communities who are under-served by conventional models of healthcare, requiring enhanced interventions to reduce inequity.
    1. Cell Biology
    2. Neuroscience

    Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

    Rituparna Chakrabarti, Lina María Jaime Tobón ... Carolin Wichmann
    Ultrastructural analysis of optogenetically stimulated inner hair cell ribbon synapses reveals normally sized synaptic vesicles and enhanced vesicle docking at the active zone membrane.
    1. Stem Cells and Regenerative Medicine

    Scleraxis-lineage cells are required for tendon homeostasis and their depletion induces an accelerated extracellular matrix aging phenotype

    Antonion Korcari, Anne EC Nichols ... Alayna E Loiselle
    Age-related tendon degeneration is initiated by loss of tenocytes associated with synthesis of high-turnover rate proteoglycans and glycoproteins.
    1. Evolutionary Biology

    Mammalian forelimb evolution is driven by uneven proximal-to-distal morphological diversity

    Priscila S Rothier, Anne-Claire Fabre ... Anthony Herrel
    The diversification of hand bones in mammals was much more dynamic than those of the proximal and intermediate forearm, involving higher morphological diversity, stronger integration, and greater evolutionary lability at distal structures.
    1. Ecology

    Protein feeding mediates sex pheromone biosynthesis in an insect

    Shiyu Gui, Boaz Yuval ... Daifeng Cheng
    Protein feeding stimulates the production of sex pheromones and promotes fly mating in Bactrocera dorsalis.
    1. Computational and Systems Biology
    2. Neuroscience

    A hardware system for real-time decoding of in vivo calcium imaging data

    Zhe Chen, Garrett J Blair ... Hugh T Blair
    DeCalciOn is a low-cost open-source hardware system for real-time in vivo calcium imaging that offers capabilities for online decoding of neural population activity and delivery of short latency closed-loop feedback in freely behaving animals.