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Measurement precision offers a comprehensive perspective on good scientific practices to improve reproducibility of research results by providing means to optimize design and analysis parameters (e.g. sample size, trial count, or sample heterogeneity) in accordance with the researcher’s goals.

The dendrite branching receptor HPO-30 modulates actin dynamics by binding to both WAVE complex and actin filaments.

A combination of electrophysiological, electrochemical, and anatomical experiments sheds new light on how the complex neurotransmitter repertoire of dopaminergic neurons in the brain is regulated by proteins of the neurexin family.

Artificial RNA interference is a novel loss-of-function method for highly stringent target validation in oncology and beyond.

GABAergic interneurons coordinate synchronous muscle contractions along the length of the fruit fly larva to control the duration between peristaltic waves and locomotion speed.

A colloid fractal cluster model provides a quantitative link between the atomistic features of an intrinsically disordered polypeptide and the spatial organization of the biomolecular condensate it forms.

Specific inhibition of cyclin-dependent kinase-like 5 (CDKL5), a kinase linked to a severe neurodevelopmental disorder, demonstrates an important role in the regulation of excitatory hippocampal synapses and synaptic plasticity that was not previously appreciated in rodent knock-out models.

Binding of the second messenger inositol 1,4,5-trisphosphate to its intracellular receptor drives interaction between the intracellular Ca2+ sensor STIM and the plasma membrane localized Ca2+ channel Orai and raises the level of store-operated Ca2+ entry in mammalian cells.