Browse our latest research

Page 507 of 1,838
    1. Neuroscience

    A stable, distributed code for cue value in mouse cortex during reward learning

    David J Ottenheimer, Madelyn M Hjort ... Garret D Stuber
    Individual neurons in a surprising number of frontal cortical regions encode the value of reward-predicting olfactory cues across distinct stimulus sets and experimental sessions.
    1. Neuroscience

    Inconsistencies between human and macaque lesion data can be resolved with a stimulus-computable model of the ventral visual stream

    Tyler Bonnen, Mark AG Eldridge
    A 'stimulus-computable' modeling approach resolves apparent inconsistencies between human and monkey lesion data, implicating perirhinal cortex in visual object perception.
    1. Evolutionary Biology
    2. Genetics and Genomics

    On the limits of fitting complex models of population history to f-statistics

    Robert Maier, Pavel Flegontov ... David Reich
    Many published findings about population history that rely on inference of admixture graph models fitted to f-statistics are not robust since the method is generally inappropriate for extracting new information about population history.
    1. Computational and Systems Biology
    2. Neuroscience

    Model discovery to link neural activity to behavioral tasks

    Jamie D Costabile, Kaarthik A Balakrishnan ... Martin Haesemeyer
    Model identification of neural encoding is an accessible system for the analysis of neural data that allows identifying and characterizing arbitrary relationships between neural activity and task-related variables such as behavior, stimuli, or internal states.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Differential translation of mRNA isoforms underlies oncogenic activation of cell cycle kinase Aurora A

    Roberta Cacioppo, Hesna Begum Akman ... Catherine Lindon
    Post-transcriptional regulation of Aurora Kinase A (AURKA) through alternative polyadenylation of its mRNA determines miRNA influence and is a feature of cell cycle-specific AURKA expression whose impairment leads to acquisition of cancer phenotypes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Joint inference of evolutionary transitions to self-fertilization and demographic history using whole-genome sequences

    Stefan Strütt, Thibaut Sellinger ... Stefan Laurent
    Transitions from outcrossing to selfing, a major shift in mating systems, create a specific signature in intra-specific genetic polymorphisms, which can be used to infer the demographic history of populations and acquire valuable insights about the evolution of recombination rates.
    1. Ecology
    2. Evolutionary Biology

    Spatiotemporal ecological chaos enables gradual evolutionary diversification without niches or tradeoffs

    Aditya Mahadevan, Michael T Pearce, Daniel S Fisher
    Evolution of multiple closely related strains with host-pathogen-like interactions but only one niche and no tradeoffs, can give rise to a spatiotemporally chaotic ecological state that continually diversifies even with generalist mutations that slow the evolution.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Integrating contact tracing and whole-genome sequencing to track the elimination of dog-mediated rabies: An observational and genomic study

    Kennedy Lushasi, Kirstyn Brunker ... Katie Hampson
    Contact tracing data reveal how a One Health approach underpinned by dog vaccination interrupts rabies transmission in reservoir populations removing the risk to humans, while virus genome data highlight the importance of surveillance and sustained dog vaccination in connected populations.
    1. Medicine

    RANK+TLR2+ myeloid subpopulation converts autoimmune to joint destruction in rheumatoid arthritis

    Weixin Zhang, Kathleen Noller ... Xu Cao
    The sialylation of RANK+TLR2+ monocytes contributes to osteoclastogenesis and bone destruction in rheumatoid arthritis.
    1. Evolutionary Biology
    2. Plant Biology

    Environment as a limiting factor of the historical global spread of mungbean

    Pei-Wen Ong, Ya-Ping Lin ... Cheng-Ruei Lee
    After domestication, the cultivation range expansion of crops was not solely dictated by human activity but instead constrained by climatic factors, which in turn resulted in distinct phenotypic characteristics of locally adaptive landraces.