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The H3K36 and H3K27 histone methyltransferases MES-4 and PRC2 protect survival of the nascent germline in Caenorhabditis elegans by repressing expression of X-linked genes, including the key transcription factor LIN-15B.

Single-cell RNA-sequencing, spatial genomics, and histological analyses reveal that cold-induced brown adipose neogenesis is a complex adaptive response to elevated metabolic demand involving dynamic interactions between recruited immune cells and a subpopulation of poised adipocyte progenitors.

Three-dimensional imaging and automated, brain-wide cell counting yield new insight into the diversity of neurons that connect the brain to the spinal cord and their different sensitivity to spinal cord damage.

μCT-aided study illuminates the cranial endoskeleton and interrelationships of the Permian actinopterygian †Brachydegma, which is now excluded from crown neopterygians despite exhibiting a double jaw joint.

Canadian COVID-19 travel restrictions imposed in March 2020 greatly reduced SARS-CoV-2 importations, but were insufficient to prevent new sublineages of similar transmissibility from being introduced and replacing early sublineages.

In a mouse model of Parkinson's disease, deep brain stimulation of the subthalamic nucleus disrupts movement-related neural activity in parallel with relieving motor symptoms.

Genetically engineered, CD73-redirected human NK cells show potent antitumor activity in vivo by impairing adenosinergic activity of CD73 in cancer.

DIP2 is a conserved protein across fungi and animals that regulates specific diacylglycerol pools by diverting them to storage lipid biosynthesis to enable cellular homeostasis and adaptations.

Switches in cell state downstream of pathogen exposure are driven by a deeply conserved disorder-to-order phase transition in an immunity signaling network.

Scalar irradiance microsensor measurements performed inside the tissue of living corals show that absorption and fluorescence emission by host pigments produce dramatic spectral alterations in the light environment experienced by the symbionts.