The active small G protein, Arl15-GTP, interacts with the MH2 domain of Smad4 and positively regulates the TGFß family signaling pathway by promoting the assembly of the Smad-complex.
Mark Richards, Emmanuel Nwadozi ... Lena Claesson-Welsh
Organ and vessel-type-specific differences in endothelial cell barrier composition and properties uncover the distinct importance of the major tight junction protein Claudin5 in restricting agonist-induced leakage.
Jolle Wolter Jolles, Matthew MG Sosna ... Iain D Couzin
Detailed tracking of live predators attacking live schools of prey reveals the crucial interplay between predator attack strategy and prey behaviour and positioning in determining the predation risk within mobile animal groups.
Invasive electrophysiological recordings from the human brain reveal that different mood levels translate into different brain states that predispose subjects to make risky or safe decisions.
A critical analysis of recent single-cell transcriptomic studies of Drosophila blood cells confirms the extreme plasticity of the major phagocyte class, identifies a new class of blood cell, and suggests relationships to blood cells in other insects.
The sour receptor, OTOP1, and related proton channel OTOP3 are steeply activated by extracellular protons while OTOP2 is active over a broad pH range and differences in gating are partly attributed to extracellular domains.
Daniel J Richter, Romain Watteaux ... Olivier Jaillon
Analysis of genomic DNA composition of surface plankton communities reveals a stable, ocean basin-scale plankton biogeography that emerges from the intertwined effects of environmental variations and currents.
A novel approach together with a user-friendly web-based analytic tool, coined 'REAP', was proposed to improve the quantitative assessment of dose-response relationship and drug potency.
