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Drug targeting Nsp1-ribosome interaction shows rescue of Nsp1-mediated translation inhibition and has antiviral activity against SARS-CoV-2.

The MCM-binding protein (MCMBP) promotes the hexamer assembly of the replicative MCM2–7 helicase by interacting with the nascent MCM3 subunit, playing a key role in achieving high expression levels of the functional MCM2–7 helicase for maintaining genome integrity.

The first demonstration that cellular ATP homeostasis suppresses high volatility of cellular ATP levels to ensure proteostasis that prevents accumulation of cytotoxic protein aggregation.

The interplay of the host metabolic reprogramming, its negative association with antiviral biological signaling pathways and the IFN-mediated host antiviral mechanism during Crimean–Congo hemorrhagic fever orthonairovirus (CCHFV) infection could provide attractive options for therapeutic intervention of CCHF.

Human sensorimotor learning is associated with changes in the structure of cognitive and motor functional brain networks, and reconfiguration processes occurring in these networks are associated with distinct patterns of subject learning and relearning.

Tissue-level cell tracking and analysis of actomyosin and N-cadherin adhesion dynamics, coupled with disruption of the regulatory gene Shroom3, reveals region-specific cell behaviors along the anteroposterior axis during neural tube closure.

A comprehensive analysis of mutant animal model shows the important role of KDM6B and how it cooperates with TFDP1 to achieve its functional specificity in regulating Trp53 expression to control the fate of cranial neural crest cells during palatogenesis.

Proline is essential for osteoblast differentiation and bone formation by facilitating the production of proline-enriched osteoblast proteins.

Intercellular communication is critical for organ function, and the role of innervation in mediating this communication is of relevance to many fields, including developmental biology, neuroendocrinology, and disease pathophysiology.

Replication stress induces phosphorylation events within RIF1 intrinsically disordered region that are essential for RIF1's role in DNA replication fork protection.