Vivian Vasconcelos Costa, Michelle A Sugimoto ... Mauro Martins Teixeira
An inadequate engagement of the inflammation resolution circuit centred on Annexin A1 contributes to the excessive inflammation observed in severe DENV infection, suggesting FPR2/ALX agonists as a therapeutic target for dengue disease.
Justin YA Doritchamou, Jonathan P Renn ... Patrick E Duffy
VAR2CSA, the leading candidate antigen for a placental malaria vaccine, displays epitopes targeted by naturally acquired broadly neutralizing antibodies of African multigravidae.
Malaria parasites target a polyprenyl synthase enzyme to the apicoplast organelle and require its activity to produce long-chain linear isoprenoids necessary for apicoplast biogenesis.
Elena Fernández Álvaro, Phat Voong Vinh ... Stephen Baker
The oral carbapenem 'Tebipenem' has high level antibacterial activity against highly drug-resistant Shigella, and its mode of action and pharmacokinetics make it suitable for the treatment of severe diarrhoea caused by highly drug-resistant bacteria.
Elvira Forte, Mirana Ramialison ... Milena B Furtado
Adult mouse fibroblasts maintain an embryonic gene expression signature, inherited from their organ of origin, that is important for organ homeostasis and fibrosis, and may assist in targeting fibrotic diseases in an organ-specific manner.
VGF was identified as a factor secreted from thalamocortical axons essential for the cytoarchitectonic features of neocortical layer 4 in the sensory areas in mice.
Jennifer Patritti Cram, Jianqiang Wu ... Nancy Ratner
In a mouse model of neurofibromatosis type 1, the purinergic receptor P2RY14 is a key regulator of Schwann cell precursor self-renewal and proliferation, of neurofibroma tumor initiation and of mouse survival.
Joshua Hatterschide, Paola Castagnino ... Elizabeth A White
Papillomavirus E7 proteins activate the YAP1 oncogene in basal epithelial cells by degrading PTPN14, in doing so promoting basal cell retention and contributing to carcinogenesis.
Kelsie RS Doering, Xuanjin Cheng ... Stefan Taubert
Animal survival in hypoxia requires the classical hypoxia-inducible factor (HIF) signalling pathway, but in the nematode worm C. elegans, a new signalling pathway involving the nuclear receptor NHR-49/PPARalpha is as important for hypoxia survival as the HIF pathway.
Macrophages use integrin-dependent 3D movement and cell protrusiveness, which control cell motility and space exploration as a prerequisite for optimal clearance of particles and dead cells by macrophage networks.
