Cryogenic electron microscopy of the ryanodine receptor 1 at near-atomic resolution reveals a calcium-inactivated conformation and uncovers a conserved lipid-binding site.
Elisabeth A Kilroy, Amanda C Ignacz ... Clarissa A Henry
Depending upon the parameters used, neuromuscular stimulation can have beneficial or deleterious impacts on muscle structure and function in an animal model of Duchenne muscular dystrophy.
Modulation of dermal adipocytes contributes to skin homeostasis and provides a promising new therapeutic strategy in the treatment of EGFRI-related skin disorders.
TIGAR deficiency in cholinergic neuron enhanced intracellular acetyl-CoA levels and pyruvate dehydrogenase flux into the TCA cycle that drives increased cholinergic tone with reduced heart rate and blood pressure and raised resistance against the paralytic curare and cold-induced hypothermia.
Elena Vasileva, Mikako Warren ... James F Amatruda
A zebrafish genetic model of Ewing sarcoma, a pediatric bone cancer, showed how molecules in the normal tissue can support tumor cells, and identified a therapeutic compound that slows tumor growth.
Edward R Kastenhuber, Marisa Mercadante ... Lewis Cantley
Factor Xa and thrombin cleavage activate SARS-CoV-2 spike, widening the scope of host proteases involved in coronavirus entry and demonstrating the potential for dual anticoagulant/antiviral drugs.
Satvika Burugupalli, Adam Alexander T Smith ... Barwon Infant Study Investigator team
Plasma lipidomic profiling in pregnancy, infancy and early childhood provides a framework to define the relationship between lipid metabolism and health outcomes in early childhood.
Maria C Perez-Flores, Eric Verschooten ... Ebenezer N Yamoah
In vitro and in vivo physiological analyses reveal that mammalian auditory neuron intrinsic mechanical sensitivity contributes to sound-evoked activity and explains other previously unexplained auditory neuron features.
Electrical and biomechanical stimuli directly bias cortical signal transduction and cytoskeletal waves, and the direct bias induced by an electric field develops slowly compared to the rapid surface-receptor-mediated response to chemotactic gradients.
