Browse our latest research

Page 659 of 1,751
    1. Developmental Biology

    Nephronectin-integrin α8 signaling is required for proper migration of periocular neural crest cells during chick corneal development

    Justin Ma, Lian Bi ... Peter Lwigale
    A new role for nephronectin and integrin α8 signaling during neural crest cell migration in the developing cornea has been identified.
    1. Cell Biology
    2. Neuroscience

    Tadr is an axonal histidine transporter required for visual neurotransmission in Drosophila

    Yongchao Han, Lei Peng, Tao Wang
    TADR (torn and diminished rhabdomeres)-dependent histidine transporting is required for de novo synthesis of histamine and for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
    1. Neuroscience

    Stimulus dependence of directed information exchange between cortical layers in macaque V1

    Marc Alwin Gieselmann, Alexander Thiele
    Stimulus-induced causal interactions in the gamma range can flow in direction opposite to the canonical microcircuit, violating the notion that they are signatures of feedforward communication.
    1. Neuroscience

    Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5

    Tobias J Buscham, Maria A Eichel-Vogel ... Hauke B Werner
    When oligodendrocytes lack expression of the low-abundant myelin protein CMTM5, central nervous system axons are myelinated normally but subsequently degenerate involving a Wallerian-like pathomechanism.
    1. Structural Biology and Molecular Biophysics

    A saturation-mutagenesis analysis of the interplay between stability and activation in Ras

    Frank Hidalgo, Laura M Nocka ... John Kuriyan
    Deep mutagenesis experiments demonstrate that while cancer-causing mutations in Ras selectively alter regulatory interactions with GTPase-activating proteins, Ras is also activated by many mutations that decrease protein stability.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Parallel evolution of Pseudomonas aeruginosa phage resistance and virulence loss in response to phage treatment in vivo and in vitro

    Meaghan Castledine, Daniel Padfield ... Angus Buckling
    Parallel evolutionary dynamics were found in vivo and in vitro, showing that laboratory studies can be predictive of certain phenotypic outcomes of clinical phage therapy (phage-mediated decolonization).
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption

    Chenlu Zhang, Zehan Hu ... Tamia A Harris-Tryon
    SPRRs are bactericidal proteins, stimulated in the sebaceous gland by lipopolysaccharide, that defend the host against infection through bacterial membrane binding and disruption.
    1. Neuroscience

    Humans perseverate on punishment avoidance goals in multigoal reinforcement learning

    Paul B Sharp, Evan M Russek ... Eran Eldar
    Humans perseverate on previously instructed goals in a novel multigoal reinforcement learning task, and do this to a greater extent for punishment avoidance goals.
    1. Genetics and Genomics

    Mosaic cis-regulatory evolution drives transcriptional partitioning of HERVH endogenous retrovirus in the human embryo

    Thomas A Carter, Manvendra Singh ... Cédric Feschotte
    A 'phyloregulatory' approach reveals how human endogenous retrovirus type-H, a family of human endogenous retroviruses, diversified its regulatory sequences through multiple mutational mechanisms to partition its transcriptional activity spatially and temporally within the human embryo.
    1. Structural Biology and Molecular Biophysics

    Identification of electroporation sites in the complex lipid organization of the plasma membrane

    Lea Rems, Xinru Tang ... Lucie Delemotte
    Advanced data analysis of molecular dynamics simulations of complex lipid membranes provides a quantitative and predictive model of the molecular features that control electroporation.