Browse our latest research

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    1. Microbiology and Infectious Disease
    2. Neuroscience

    Neuroanatomical abnormalities in a nonhuman primate model of congenital Zika virus infection

    Danielle Beckman, Adele MH Seelke ... Eliza Bliss-Moreau
    Fetal Zika virus’ direct infection of the brain causes neuroanatomical pathology that tracks with the brain development, following a caudal-to-rostral trajectory, even in individuals who do not develop microcephaly.
    1. Neuroscience

    A dentate gyrus-CA3 inhibitory circuit promotes evolution of hippocampal-cortical ensembles during memory consolidation

    Hannah Twarkowski, Victor Steininger ... Amar Sahay
    Parvalbumin inhibitory neuron-mediated feed-forward inhibition in dentate gyrus-CA3 circuit governs time-dependent re-organization of memory traces in hippocampal-cortical networks to support systems consolidation.
    1. Neuroscience

    Environmental enrichment enhances patterning and remodeling of synaptic nanoarchitecture as revealed by STED nanoscopy

    Waja Wegner, Heinz Steffens ... Katrin I Willig
    Two-color time-lapse superresolution imaging of the synaptic nanoorganization in vivo uncovers highly dynamic spine heads and PSD95 assemblies that are less variable in size but more dynamic in their PSD95 nanoorganization after environmental enrichment.
    1. Developmental Biology
    2. Evolutionary Biology

    Architecture and evolution of the cis-regulatory system of the echinoderm kirrelL gene

    Jian Ming Khor, Charles A Ettensohn
    The transcriptional control system of a sea urchin gene reveals the deep evolutionary conservation of a gene regulatory network underlying morphogenesis.
    1. Neuroscience

    NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats

    JP Johnson, Thilo Focken ... James R Empfield
    NBI-921352 (formerly XEN901) is a precision medicine in development for individuals with SCN8A gain-of-function mutations causing SCN8A related epilepsy syndrome (SCN8A-RES), as well as other epilepsy indications, include adult focal onset seizures (FOS).
    1. Epidemiology and Global Health
    2. Medicine

    External validation of a mobile clinical decision support system for diarrhea etiology prediction in children: A multicenter study in Bangladesh and Mali

    Stephanie Chow Garbern, Eric J Nelson ... Daniel T Leung
    A smartphone app incorporating clinical prediction models using patient-specific and location-specific data sources in a modular approach could predict viral-only etiology of diarrhea in children under five in Bangladesh and Mali.
    1. Cancer Biology
    2. Cell Biology

    Confined migration promotes cancer metastasis through resistance to anoikis and increased invasiveness

    Deborah Fanfone, Zhichong Wu ... Gabriel Ichim
    A biomechanical approach inducing confined cell migration reveals that mechanical stress has a profound effect on cancer cell survival.
    1. Evolutionary Biology

    Experimental evidence that uniformly white sclera enhances the visibility of eye-gaze direction in humans and chimpanzees

    Fumihiro Kano, Yuri Kawaguchi, Yeow Hanling
    Experiments showed that uniformly white sclera, one distinguishing feature of human eyes, facilitates gaze perception across species, suggesting that this eye feature evolved for conspecific communication in humans.
    1. Neuroscience

    Microsaccades as a marker not a cause for attention-related modulation

    Gongchen Yu, James P Herman ... Richard J Krauzlis
    Midbrain neurons display attention-related modulation even in the absence of microsaccades, demonstrating that shifts of attention can be dissociated from the generation of microsaccades.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Temperature evolution following joint loading promotes chondrogenesis by synergistic cues via calcium signaling

    Naser Nasrollahzadeh, Peyman Karami ... Dominique P Pioletti
    The loading-induced temperature evolution phenomenon in the knee joint modulates chondrogenic cells response to loading and accordingly opens a new paradigm that is coined 'thermo-mechanobiology'.