Browse our latest research

Page 662 of 1,751
    1. Developmental Biology

    Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

    Brogan Ashley, Claire Simner ... Jane K Cleal
    Active uptake and metabolism of maternal vitamin D by the placenta determine fetal exposure to vitamin D and how vitamin D regulates the placental transcriptome, which is also determined by its underlying epigenetic landscape, and proteome.
    1. Biochemistry and Chemical Biology
    2. Ecology

    Aggregation pheromone 4-vinylanisole promotes the synchrony of sexual maturation in female locusts

    Dafeng Chen, Li Hou ... Xianhui Wang
    4-Vinylanisole acts as maturation-accelerating pheromone to synchronize oocyte maturation of female adults in locusts.
    1. Immunology and Inflammation

    Inhibition of SHP-1 activity by PKC-θ regulates NK cell activation threshold and cytotoxicity

    Aviad Ben-Shmuel, Batel Sabag ... Mira Barda-Saad
    Phosphorylation of the phosphatase SHP-1 by PKC-θ in natural killer (NK) cells induces SHP-1 inhibition, revealing a novel molecular pathway that sustains NK cell activation threshold.
    1. Medicine
    2. Microbiology and Infectious Disease

    Gut microbiota induces high platelet response in patients with ST segment elevation myocardial infarction after ticagrelor treatment

    Xi Zhang, Xiaolin Zhang ... Yaling Han
    After myocardial infarction, gut microbiota affects platelet aggregation rate by regulating the absorption and metabolism of ticagrelor.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Chemotactic smoothing of collective migration

    Tapomoy Bhattacharjee, Daniel B Amchin ... Sujit Sankar Datta
    Studies of bacterial chemotaxis reveal how limitations in single-cell sensing of stimuli influence large-scale population morphology.
    1. Neuroscience

    Target-specific control of olfactory bulb periglomerular cells by GABAergic and cholinergic basal forebrain inputs

    Didier De Saint Jan
    Muscarinic excitation of a previously ignored subtype of periglomerular interneuron in the olfactory bulb by endogenous synaptic release of acetylcholine.
    1. Genetics and Genomics

    Application of ATAC-Seq for genome-wide analysis of the chromatin state at single myofiber resolution

    Korin Sahinyan, Darren M Blackburn ... Vahab D Soleimani
    Single myofiber ATAC-Seq provides assessment of chromatin accessibility of a single myofiber without the confounding effects of other cell types present in skeletal muscle.
    1. Neuroscience

    NMDA receptors in visual cortex are necessary for normal visuomotor integration and skill learning

    Felix C Widmer, Sean M O'Toole, Georg B Keller
    Prediction error responses in layer 2/3 of mouse visual cortex are shaped by experience-dependent modifications of the local cortical circuit.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition

    Kerry Marie Goodman, Phinikoula S Katsamba ... Barry Honig
    Surface plasmon resonance studies reveal that clustered protocadherins have precisely tuned trans homophilic binding interactions and promiscuous but variable cis interactions, consistent with the requirement of forming error-free linear molecular zippers used by mammalian neurons to distinguish self from nonself.
    1. Immunology and Inflammation

    Galvanic current activates the NLRP3 inflammasome to promote Type I collagen production in tendon

    Alejandro Peñin-Franch, José Antonio García-Vidal ... Pablo Pelegrín
    Cellular, genetic, and biochemical assays shows that the application of a specific type of currents in mouse tendons induces an inflammatory response that favors the regeneration of the tissue, being a treatment for chronic tendinopathy lesions.