Browse our latest research

Page 705 of 1,840
    1. Microbiology and Infectious Disease

    Transposon mutagenesis in Mycobacterium abscessus identifies an essential penicillin-binding protein involved in septal peptidoglycan synthesis and antibiotic sensitivity

    Chidiebere Akusobi, Bouchra S Benghomari ... Eric J Rubin
    PBP-lipo is an essential cell-wall synthesis enzyme in Mycobacterium abscessus that localizes to the septum and whose expression is required for normal cell growth and division, as well as mediating sensitivity to several antibiotics including the β-lactams, ampicillin, and amoxicillin.
    1. Developmental Biology

    Strength of interactions in the Notch gene regulatory network determines patterning and fate in the notochord

    Héctor Sánchez-Iranzo, Aliaksandr Halavatyi, Alba Diz-Muñoz
    Interaction strength in Notch signaling determines lateral inhibition patterning and drives fate in the unidimensional cell arrangement of the zebrafish notochord.
    1. Cancer Biology
    2. Computational and Systems Biology

    Individualized discovery of rare cancer drivers in global network context

    Iurii Petrov, Andrey Alexeyenko
    Method NEAdriver employs knowledge from global networks to predict novel cancer driver genes in an individualized manner, which is done by accounting for mutations’ co-occurrence in each tumor genome and rigorous statistical evaluation.
    1. Evolutionary Biology
    2. Neuroscience

    Neocortical pyramidal neurons with axons emerging from dendrites are frequent in non-primates, but rare in monkey and human

    Petra Wahle, Eric Sobierajski ... Gundela Meyer
    Archived histological material from tracing studies, immunohistochemistry, and Golgi impregnations allowed to discover a so far unrecognized structural difference, potentially of functional importance, between neocortical pyramidal neurons of rodent, carnivore, and ungulate as compared to monkey and man.
    1. Developmental Biology
    2. Plant Biology

    Using positional information to provide context for biological image analysis with MorphoGraphX 2.0

    Sören Strauss, Adam Runions ... Richard S Smith
    MorphoGraphX is a user-friendly image processing software primarily aimed at segmenting 3D biological images into cells, quantifying cellular gene expression and growth, and understanding these data in the spatial context of developing organs.
    1. Neuroscience

    Social-affective features drive human representations of observed actions

    Diana C Dima, Tyler M Tomita ... Leyla Isik
    Social-affective features predict the perceived similarity of real-world actions better than, and independently of, visual and action-related features, and are extracted at the final stage of a temporal gradient in the brain.
    1. Neuroscience

    A neural mechanism for detecting object motion during self-motion

    HyungGoo R Kim, Dora E Angelaki, Gregory C DeAngelis
    Neural recordings from macaque area MT reveal a novel mechanism for detecting moving objects during self-motion, involving neurons with incongruent tuning for depth from motion parallax and binocular disparity cues.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Subtype-specific responses of hKv7.4 and hKv7.5 channels to polyunsaturated fatty acids reveal an unconventional modulatory site and mechanism

    Damon JA Frampton, Koushik Choudhury ... Sara I Liin
    Polyunsaturated fatty acids facilitate or impede Kv7 channel activation, depending on channel subtype and their dominant functional site(s).
    1. Cell Biology

    Reducing lipid bilayer stress by monounsaturated fatty acids protects renal proximal tubules in diabetes

    Albert Pérez-Martí, Suresh Ramakrishnan ... Matias Simons
    Monounsaturated fatty acids protect against DKD by enhancing membrane fluidity and decreasing ER lipid bilayer stress in renal proximal tubules.
    1. Physics of Living Systems

    Glycan processing in the Golgi as optimal information coding that constrains cisternal number and enzyme specificity

    Alkesh Yadav, Quentin Vagne ... Madan Rao
    A mathematical model of glycosylation in the Golgi apparatus to investigate how the fidelity of synthesising a complex glycan distribution at the plasma membrane depends on parameters such as the number of Golgi cisternae or enzyme specificity.