Browse our latest research

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    1. Cancer Biology

    ZHX2 promotes HIF1α oncogenic signaling in triple-negative breast cancer

    Wentong Fang, Chengheng Liao ... Qing Zhang
    ZHX2 controls HIF1α oncogenic signaling and tumorigenesis in triple-negative breast cancer.
    1. Developmental Biology

    Coronary blood vessels from distinct origins converge to equivalent states during mouse and human development

    Ragini Phansalkar, Josephine Krieger ... Kristy Red-Horse
    Endothelial cells from separate cardiac lineages start off in distinct transcriptional states, but over the course of development converge into transcriptional and functional states which are unrelated to lineage and which are conserved between mouse and human.
    1. Neuroscience

    Emergence and function of cortical offset responses in sound termination detection

    Magdalena Solyga, Tania Rinaldi Barkat
    Cortical offset responses are not only inherited from the periphery but also amplified and de novo generated, and preventing them decreases the ability to detect sound termination.
    1. Immunology and Inflammation

    Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder

    Beibei Wu, Laura Rice ... Sinisa Savic
    Human CRACR2A insufficiency underlies progressive loss of immune competence by uncoupling TCR activation from Ca2+ and MAPK signaling and should be included within the group of combined immunodeficiency disorders in the IEI classification.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface

    Martin Houlard, Erin E Cutts ... Kim Nasmyth
    Chromosome condensation by condensin II is inhibited during interphase by direct interaction with MCPH1, which regulates opening of the condensin II interface between SMC2 and NCAPH2, in a similar fashion to how WAPL regulates Cohesin.
    1. Cancer Biology
    2. Cell Biology

    Cyclin F drives proliferation through SCF-dependent degradation of the retinoblastoma-like tumor suppressor p130/RBL2

    Taylor P Enrico, Wayne Stallaert ... Michael J Emanuele
    The SCF-family of ubiquitin ligases regulates the key cancer proliferation node by controlling the degradation of RB-like tumor suppressor RBL2/p130.
    1. Physics of Living Systems

    Stochastic social behavior coupled to COVID-19 dynamics leads to waves, plateaus, and an endemic state

    Alexei V Tkachenko, Sergei Maslov ... Nigel Goldenfeld
    Time-varying heterogeneous social activity explains transient suppression of epidemic waves followed by long plateaus and eventual transition towards the endemic state of an emergent pathogen, such as COVID-19.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A genome-phenome association study in native microbiomes identifies a mechanism for cytosine modification in DNA and RNA

    Weiwei Yang, Yu-Cheng Lin ... Laurence Ettwiller
    A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Molecular architecture of the human tRNA ligase complex

    Alena Kroupova, Fabian Ackle ... Martin Jinek
    Biochemical and structural investigations of the human tRNA ligase complex reveal the details of its molecular assembly and provide insights into the reaction mechanism of its catalytic subunit.
    1. Cancer Biology
    2. Cell Biology

    Rpl24Bst mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K

    John RP Knight, Nikola Vlahov ... Owen J Sansom
    Signalling that maintains rapid translation elongation in KRAS-mutant colorectal cancer models can be targeted by mutation of the ribosomal protein RPL24 to suppress tumour proliferation.