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    1. Microbiology and Infectious Disease

    Characterization of the endogenous DAF-12 ligand and its use as an anthelmintic agent in Strongyloides stercoralis

    Zhu Wang, Mi Cheong Cheong ... David J Mangelsdorf
    Regulation of a nuclear receptor signaling pathway may cure the often-lethal disease caused by the endemic parasitic roundworm, Strongyloides stercoralis.
    1. Neuroscience

    Rat sensitivity to multipoint statistics is predicted by efficient coding of natural scenes

    Riccardo Caramellino, Eugenio Piasini ... Davide Zoccolan
    Visual sensitivity to correlation patterns in rats matches that previously measured in humans, as well as predictions from efficient coding theory based on the statistics of natural images.
    1. Cell Biology

    ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals

    Natalya Pashkova, Lokesh Gakhar ... Robert C Piper
    The family of ANTH domain proteins serve as adaptors to endocytose ubiquitinated proteins from the cell surface.
    1. Plant Biology

    Expression of a CO2-permeable aquaporin enhances mesophyll conductance in the C4 species Setaria viridis

    Maria Ermakova, Hannah Osborn ... Susanne von Caemmerer
    The SiPIP2;7 aquaporin is a functional CO2 pore that can be used to improve CO2 diffusion at the interface between the airspace and leaf mesophyll which limits C4 photosynthesis.
    1. Neuroscience

    Control of neurotransmitter release by two distinct membrane-binding faces of the Munc13-1 C1C2B region

    Marcial Camacho, Bradley Quade ... Christian Rosenmund
    Two different binding modes of the Munc13-1 C­1C2B region govern synaptic vesicle priming and neurotransmitter release probability.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Reversible phosphorylation of cyclin T1 promotes assembly and stability of P-TEFb

    Fang Huang, Trang TT Nguyen ... Koh Fujinaga
    Cyclin T1 phosphorylation determines levels of P-TEFb via stabilizing interactions between cyclin T1 and CDK9.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation

    Xiao-Tong Lin, Hong-Qiang Yu ... Chuan-Ming Xie
    Using IGF2BP1-PLK1 axis as an example, targeting oncogenic signaling represents a direction treatment for HCC patients with high FBXO45 expression.
    1. Neuroscience

    Maturation of persistent and hyperpolarization-activated inward currents shapes the differential activation of motoneuron subtypes during postnatal development

    Simon A Sharples, Gareth B Miles
    Electrophysiological recordings from mouse spinal motoneurons reveal key roles for ion channels in establishing the differential activation of motoneuron subtypes during postnatal development.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1

    Rania Elsabrouty, Youngah Jo ... Russell A DeBose-Boyd
    Type 1 polyisoprenoid diphosphate phosphatase (PDP1) contributes to interconversion of isoprenols and isoprenylpyrophosphates, balancing the sterol and nonsterol branches of the mevalonate pathway by regulating ERAD of HMG CoA reductase and ER-to-Golgi transport of UBIAD1.
    1. Immunology and Inflammation
    2. Structural Biology and Molecular Biophysics

    Neutrophil-mediated oxidative stress and albumin structural damage predict COVID-19-associated mortality

    Mohamed A Badawy, Basma A Yasseen ... Sameh Saad Ali
    Electron paramagnetic resonance spectroscopy quantitatively correlates structural damages of serum albumin with COVID-19 severity and mortality thus suggesting albumin replacement therapy as a strategy to rescue patients at risk of mortality.