Human CRACR2A insufficiency underlies progressive loss of immune competence by uncoupling TCR activation from Ca2+ and MAPK signaling and should be included within the group of combined immunodeficiency disorders in the IEI classification.
Chromosome condensation by condensin II is inhibited during interphase by direct interaction with MCPH1, which regulates opening of the condensin II interface between SMC2 and NCAPH2, in a similar fashion to how WAPL regulates Cohesin.
Alexei V Tkachenko, Sergei Maslov ... Nigel Goldenfeld
Time-varying heterogeneous social activity explains transient suppression of epidemic waves followed by long plateaus and eventual transition towards the endemic state of an emergent pathogen, such as COVID-19.
A novel DNA/RNA modifying enzyme catalyzing a previously unknown 5-carbamoyloxymethylcytosine modification has been discovered using a novel framework called Metagenomics Genome-Phenome Association.
Biochemical and structural investigations of the human tRNA ligase complex reveal the details of its molecular assembly and provide insights into the reaction mechanism of its catalytic subunit.
Signalling that maintains rapid translation elongation in KRAS-mutant colorectal cancer models can be targeted by mutation of the ribosomal protein RPL24 to suppress tumour proliferation.
Mechanistic studies of glutamine synthetase reveals how the complex quaternary structure organizations of a supramolecular enzyme provides a platform necessary for intricate activity regulation machinery to take place.
Benjamin D Gastfriend, Hideaki Nishihara ... Eric V Shusta
Activation of Wnt/β-catenin signaling in endothelial progenitors derived from human pluripotent stem cells partially induces the specialized blood–brain barrier phenotype while the same treatment in matured endothelial cells is less efficacious.
