Browse our latest research

Page 708 of 1,840
    1. Evolutionary Biology
    2. Genetics and Genomics

    Radiocarbon and genomic evidence for the survival of Equus Sussemionus until the late Holocene

    Dawei Cai, Siqi Zhu ... Yu Jiang
    The first nuclear genomes of the Equus (Sussemionus) ovodovi enable us to reconstruct the speciation and extinction trajectory of this lineage.
    1. Ecology
    2. Neuroscience

    Unique neural coding of crucial versus irrelevant plant odors in a hawkmoth

    Sonja Bisch-Knaden, Michelle A Rafter ... Bill S Hansson
    The sense of smell of female hawkmoths has evolved to find the intense odor of floral nectar sources as well as inconspicuous scents of oviposition sites within a complex olfactory landscape.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells

    Le Xiong, Erik A Tolen ... Hans R Schöler
    Time-resolved multiomics analysis during Oct4 depletion and recovery reveals concentration-dependent activities of Oct4 in controlling enhancer transcription and chromatin accessibility in mouse embryonic stem cells.
    1. Neuroscience

    Higher-order olfactory neurons in the lateral horn support odor valence and odor identity coding in Drosophila

    Sudeshna Das Chakraborty, Hetan Chang ... Silke Sachse
    Two-photon functional imaging linked to olfactory preference in Drosophila provides the first understanding of how odors are integrated, transformed, and represented in the lateral horn by an ensemble of higher-order glutamatergic lateral horn neurons.
    1. Computational and Systems Biology
    2. Neuroscience

    Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease

    Timon Merk, Victoria Peterson ... Wolf-Julian Neumann
    Advanced machine learning based brain signal decoding of grip-force as a proxy for movement vigor shows Parkinson's disease related performance reduction, suggestive of a loss of cortical vigor encoding in the absence of dopamine.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    CREB5 reprograms FOXA1 nuclear interactions to promote resistance to androgen receptor-targeting therapies

    Justin H Hwang, Rand Arafeh ... William C Hahn
    A comprehensive molecular interrogation of CREB5 interactions identified changes in protein and chromatin interactions of FOXA1 that promoted therapy resistance in prostate cancer cells.
    1. Cancer Biology
    2. Computational and Systems Biology

    Regulation of protein complex partners as a compensatory mechanism in aneuploid tumors

    Gökçe Senger, Stefano Santaguida, Martin H Schaefer
    Coordinated regulation of co-complex members compensates for aneuploidy-induced stoichiometric imbalances in human cancer.
    1. Immunology and Inflammation
    2. Neuroscience

    Single-cell profiling reveals periventricular CD56bright NK cell accumulation in multiple sclerosis

    Sabela Rodríguez-Lorenzo, Lynn van Olst ... Helga E de Vries
    Together, our multi-tissue single-cell data shows that CD56bright NK cells accumulate in the periventricular brain regions of multiple sclerosis (MS) patients, bringing NK cells back to the spotlight of MS pathology.
    1. Cell Biology

    CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

    Désirée Schatton, Giada Di Pietro ... Elena I Rugarli
    CLUH links growth signaling pathways and mitochondrial metabolism with cell cycle progression by regulating astrin-1 synthesis and stability.
    1. Neuroscience

    A dynamic clamp protocol to artificially modify cell capacitance

    Paul Pfeiffer, Federico José Barreda Tomás ... Susanne Schreiber
    Via the capacitance clamp, electrophysiologists can for the first time flexibly set an artificial membrane capacitance for neurons and other excitable cells and thereby adjust their membrane time constant independent of any conductance changes.