Jose D Aponte, David C Katz ... Benedikt Hallgrímsson
Multivariate genotype-phenotype mapping enables quantification of pathway and process-level effects on complex phenotypes and predicts phenotypic effects of novel mutations.
Juan Carlos De la Concepcion, Javier Vega Benjumea ... Mark J Banfield
Biochemical and in planta studies reveal how a rice immune receptor pair has coevolved to deliver immune responses, an important step towards understanding and engineering bespoke resistance to crop pathogens that threaten food security.
Prefrontal causal roles in bistable perception are dynamically changing and determined by the brain state to which the whole-brain activity pattern belongs.
Maria Podinovskaia, Cristina Prescianotto-Baschong ... Anne Spang
A novel, inexpensive, easy-to-use method to analyse traffic along the endosomal pathway in mammalian cells shows that there is coordination between Rab conversion and acidification, but almost none between Rab conversion and recycling.
Koshlan Mayer-Blackwell, Stefan Schattgen ... Andrew Fiore-Gartland
Distance-based TCR analysis enables grouping of biochemically similar clonotypes into meta-clonotypes that have increased publicity, and therefore statistical power, for population-level detection of antigen-specific T cells in infection and vaccination.
Beatriz Bano-Otalora, Matthew J Moye ... Mino DC Belle
Circadian control of neuronal excitability in the master circadian clock of a diurnal mammal as revealed by whole-cell recording and mathematical modeling.
The Mouse Action Recognition System is a computational pipeline for automated classification of social behaviors in freely interacting mice, accompanied by a graphical interface for analysis of multimodal neuroscience datasets.
The assignment of borders to foreground objects occurs in cortical columns in primate visual cortex, and first in deep layers, suggesting a central role for feedback.
