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The central RNA interference protein, human Argonaute-2, releases its target following phosphorylation on a critical loop in the protein, freeing microRNA-bound Argonaute-2 to seek out and repress additional targets.

Rat blood profiles support non-linear aging with distinct trajectory shifts, and these profiles could be used to predict non-overt illness in rats or aging intervention efficacy.

Novel cell-free biochemical experiments show that the host GTPase MxB can restrict the infection of alphaherpesviruses by disassembling the sturdy viral capsids so that they can no longer protect the viral genomes.

Partial-volume effects were found to be the current limit to imaging pial arteries with MRI, not their slow blood flow, and therefore advanced acquisition techniques achieving resolutions below 200 µm in vivo provide a more complete picture of these vessels.

Normal adipogenesis requires de novo DNA methyltransferase 3A (DNMT3A) for proper differentiation and suppression of an age-associated pathogenic inflammatory program.

Scenario-invariant representation of physical stability is found in the frontoparietal regions but not the ventral visual pathway (and ImageNet-trained convolutional neural networks), consistent with the hypothesis that computations underlying physical stability may entail forward simulations of what will happen next.

A multidisciplinary approach provides a description of the exocytic pathway that exports Salmonella Typhi's typhoid toxin from infected cells.

The cryogenic-electron microscopy structure of IL-27 bound to receptors, IL-27Rα and gp130, revealing a three-site assembly mechanism and overall topology and molecular details reminiscent of IL-6 but distinct from related IL-12 and IL-23.

A novel mechanism describes how tonic activation of nicotinic acetylcholine receptors can modulate the timing of striatal output by priming feedforward inhibition.

B-cell integrin co-stimulation promotes the formation of an actomyosin network that drives integrin-dependent immune synapse formation and B-cell activation.