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Replicating experimental evolution from ancestral proteins shows that historical contingency steadily overwhelms chance and necessity as the primary cause of evolutionary variation in molecular sequences on long phylogenetic timescales.

Wide variation in cycle threshold (Ct) values from SARS-CoV-2 RT-PCR tests over calendar time offers the potential for their broader use in public testing programmes as an ‘early-warning’ system for shifts in infectious load and hence transmission.

Cell biology analyses in Drosophila epithelial tissues reveal novel mechanisms connecting epithelial polarity proteins with Myosin-dependent cell contractility.

Structurally divergent bacterial-like mechanosensitive channels control multiple cellular functions in protozoan parasites.

The mechanism triggering HBV membrane fusion involves ERp57, a cellular protein disulfide isomerase, and ultimately leads to the exposition of a fusion peptide that was identified in the pre-S1 determinant.

Smoking, measured by both initiation and intensity, are significantly associated with an elevated expression level of ACE2 in multiple human tissues/organs, subsequently increasing the susceptibility and severity of COVID-19.

Cellular acidity, capacity for net acid extrusion, and expression of acid-base transporters in human breast carcinomas independently predict variation in proliferative activity, lymph node metastasis, and patient survival.

Mannose-sensitive hemagglutinin pili act as a braking and anchoring machine during the three-phase landing process of Vibrio cholerae.

aIC to mPFC connections are correlative and necessary both for taste novelty behavior and learning while the reciprocal connection from mPFC to aIC is correlative and necessary for novelty behavior.

A deep learning network can classify cardiac myocytes into drug-free and drugged categories and predict the impact of electrophysiological perturbation across the continuum of aging.