Browse our latest research

Page 888 of 1,761
    1. Neuroscience

    Activation of MAP3K DLK and LZK in Purkinje cells causes rapid and slow degeneration depending on signaling strength

    Yunbo Li, Erin M Ritchie ... Yishi Jin
    The activity levels of two closely related MAPKKK are differentially regulated in Purkinje neuron survival.
    1. Neuroscience

    The distinct roles of calcium in rapid control of neuronal glycolysis and the tricarboxylic acid cycle

    Carlos Manlio Díaz-García, Dylan J Meyer ... Gary Yellen
    When neurons are stimulated, calcium entry into mitochondria upregulates mitochondrial energy production, but glycolytic energy production in the cytosol is stimulated by elevated energy demand, not Ca2+ signaling.
    1. Neuroscience

    Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila

    Colleen N McLaughlin, Maria Brbić ... Hongjie Li
    Single-cell transcriptomes of olfactory receptor neurons at multiple developmental stages reveal cell-type-specific gene expression programs that underlie their development and sensory biology.
    1. Immunology and Inflammation

    Stochastic asymmetric repartition of lytic machinery in dividing CD8+ T cells generates heterogeneous killing behavior

    Fanny Lafouresse, Romain Jugele ... Salvatore Valitutti
    A fraction of human CD8+ T cells unequally partitions their lytic components during division, producing cells with heterogeneous killing capacities.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host–pathogen dynamics in lymphoblastoid cell lines

    Elliott D SoRelle, Joanne Dai ... Micah A Luftig
    Single-cell RNA sequencing highlights the influence of host–pathogen interactions and stochasticity on transcriptional and phenotypic variance in lymphoblastoid cell lines derived from Epstein–Barr virus-infected primary B cells.
    1. Cell Biology

    Stable transplantation of human mitochondrial DNA by high-throughput, pressurized isolated mitochondrial delivery

    Alexander J Sercel, Alexander N Patananan ... Michael A Teitell
    Applied pressure enables efficient isolated mitochondrial transfer and stable mitochondrial DNA (mtDNA) transplantation into a range of mtDNA-depleted cell types to restore respiration.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Kinetic sculpting of the seven stripes of the Drosophila even-skipped gene

    Augusto Berrocal, Nicholas C Lammers ... Michael B Eisen
    Live quantitative monitoring of transcriptional bursting reveals that enhancers responding to different regulators use the same kinetic strategy to produce a complex composite pattern of developmental expression.
    1. Plant Biology
    2. Structural Biology and Molecular Biophysics

    Identification of distinct pH- and zeaxanthin-dependent quenching in LHCSR3 from Chlamydomonas reinhardtii

    Julianne M Troiano, Federico Perozeni ... Gabriela S Schlau-Cohen
    Light-harvesting complex stress-related is a protein from photosynthetic green algae that prevents damage from sunlight via two distinct conformational processes, which protect against different timescales of solar fluctuations.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Global, cell non-autonomous gene regulation drives individual lifespan among isogenic C. elegans

    Holly E Kinser, Matthew C Mosley ... Zachary Pincus
    Expression of almost half of a library of fluorescent reporters distinguish long- from short-lived individual Caenorhabditis elegans, suggesting that organism-wide differences in gene expression drive future lifespan.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Formicine ants swallow their highly acidic poison for gut microbial selection and control

    Simon Tragust, Claudia Herrmann ... Heike Feldhaar
    Poison acidified crops sanitize food and limit disease transmission while at the same time structuring the gut microbiota and thus contribute to the ecological and evolutionary success of formicine ants.