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Translational evidence indicates APOE2 benefits longevity independent of its protective effects on Alzheimer’s disease, which preserved activity and the metabolism of apoE protein and associated-lipids would be key to understanding.

Projections from the prelimbic prefrontal cortex targeting the ventral striatum or the basolateral amygdala bidirectionally regulate platform-mediated active avoidance in rats.

Cryo-electron tomography reveals the structure and arrangement of the VP40 matrix protein lattice that mediates the formation of Ebola and Marburg virus particles.

A molecular mechanism for force-dependent binding of the cell adhesion proteins αE-catenin and vinculin to actin is derived from the structure of the αE-catenin actin-binding domain bound to F-actin.

Biophysical and structural studies reveal how low piconewton forces across actin enhance binding by the critical cell-cell adhesion protein α-catenin versus its force insensitive homolog vinculin.

Posterior parietal cortex encodes errors in a task-dependent manner while a large array of frontal regions predict subsequent behavioral changes in response to ambiguous errors.

Plants and humans use a shared mechanism, the eukaryotic metabolic sensor TARGET OF RAPAMYCIN protein kinase and its substrate, an RNA-binding protein called LARP1, to coordinate post-transcriptional gene expression.

Transposable elements are not reactivated in natural hybrids of the yeast Saccharomyces paradoxus, but their accumulation is genotype-specific and is not predicted by the evolutionary divergence between a hybrid's parents.

An integrative structural biology approach provides refined models of the KCNQ1-KCNE1 channel complex, which propose a new mechanism to explain how KCNE1 modulates KCNQ1 channel activation.

Recent examples demonstrate that already the transcriptional activity at lncRNA genes does have an important function on gene regulation, while the produced non-coding RNA might be dispensable.