Browse our latest research

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    1. Neuroscience

    DMT alters cortical travelling waves

    Andrea Alamia, Christopher Timmermann ... Robin L Carhart-Harris
    Psychedelics induce a pattern of cortical activity very similar to the one observed during visual perception, despite participants had shut eyes.
    1. Neuroscience

    Cerebellar patients have intact feedback control that can be leveraged to improve reaching

    Amanda M Zimmet, Di Cao ... Noah J Cowan
    A control system model of cerebellar patients' movements provides insight into the cerebellum's role in reaching and informs a virtual reality intervention to improve patient reaches.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon–anticodon pairing

    Eric D Hoffer, Samuel Hong ... Christine M Dunham
    Chemical modifications near the tRNA anticodon and specific mRNA–tRNA pairs combine to control the ribosomal three-nucleotide mRNA reading frame, essential for the sequential addition of amino acids into polypeptide chains.
    1. Computational and Systems Biology

    A large accessory protein interactome is rewired across environments

    Zhimin Liu, Darach Miller ... Sasha F Levy
    A massively multiplexed multi-condition screen shows that protein interactomes are larger than previously thought and contain highly dynamic regions that reorganize to drive or respond to cellular changes.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Artemisinin exposure at the ring or trophozoite stage impacts Plasmodium falciparum sexual conversion differently

    Harvie P Portugaliza, Shinya Miyazaki ... Alfred Cortés
    Treatment of malaria parasites with the frontline antimalarial drug artemisinin can increase the proportion of parasites that convert into transmission forms.
    1. Developmental Biology
    2. Neuroscience

    Developmental, cellular, and behavioral phenotypes in a mouse model of congenital hypoplasia of the dentate gyrus

    Amir Rattner, Chantelle E Terrillion ... Jeremy Nathans
    A mouse mutant in which nearly all dentate gyrus granule cells fail to develop provides a new window on the role of the dentate gyrus in spatial learning and memory.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    A broadly neutralizing macaque monoclonal antibody against the HIV-1 V3-Glycan patch

    Zijun Wang, Christopher O Barnes ... Amelia Escolano
    Rhesus macaques can develop broadly neutralizing antibodies (bNAbs) against the V3-glycan patch of Env that resembles human V3/N332 bNABs.
    1. Neuroscience

    Rapid purification and metabolomic profiling of synaptic vesicles from mammalian brain

    Lynne Chantranupong, Jessica L Saulnier ... Bernardo L Sabatini
    Extensive mass spectrometry-based profiling of polar metabolites within synaptic vesicles that are rapidly isolated either from cultured mouse neurons or directly from mouse brains reveals their neurotransmitter composition.
    1. Neuroscience

    Optogenetic inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron connections during behavior

    Igor Gridchyn, Philipp Schoenenberger ... Jozsef Csicsvari
    The optogenetic manipulation of hippocampal neuronal circuit activity revealed plastic changes of pyramidal-interneuron connections in behaving animals, which were primarily governed by the firing rate change of postsynaptic interneurons.
    1. Developmental Biology

    Neuronal octopamine signaling regulates mating-induced germline stem cell increase in female Drosophila melanogaster

    Yuto Yoshinari, Tomotsune Ameku ... Ryusuke Niwa
    Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.