Browse our latest research

Page 936 of 1,751
    1. Neuroscience

    VIP interneurons in mouse primary visual cortex selectively enhance responses to weak but specific stimuli

    Daniel J Millman, Gabriel Koch Ocker ... Saskia EJ de Vries
    Measurements of visual response to motion of different contrasts along with network modeling reveals a microcircuit in superficial layers of cortex that regulates the gain regime.
    1. Neuroscience

    Improving emotional-action control by targeting long-range phase-amplitude neuronal coupling

    Bob Bramson, Hanneke EM den Ouden ... Karin Roelofs
    Non-invasive manipulation of endogenously coupled neural rhythms enhances human control of social-emotional actions.
    1. Chromosomes and Gene Expression

    The S-phase-induced lncRNA SUNO1 promotes cell proliferation by controlling YAP1/Hippo signaling pathway

    Qinyu Hao, Xinying Zong ... Kannanganattu V Prasanth
    Cell cycle phase-specifically induced long non-coding RNAs regulate cell proliferation by modulating crucial cell signaling pathways.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Drivers and sites of diversity in the DNA adenine methylomes of 93 Mycobacterium tuberculosis complex clinical isolates

    Samuel J Modlin, Derek Conkle-Gutierrez ... Faramarz Valafar
    Fully assembled DNA methylomes from phylogeographically diverse clinical Mycobacterium tuberculosis complex isolates reveals 'intercellular mosaic methylation' as a source of epigenetic diversity.
    1. Microbiology and Infectious Disease

    Specificity in glycosylation of multiple flagellins by the modular and cell cycle regulated glycosyltransferase FlmG

    Silvia Ardissone, Nicolas Kint, Patrick H Viollier
    Glycosylation of flagellins with pseudaminic acid in the bacterial cytoplasm governed by an unknown type of modular glycosyltransferase harboring an N-terminal substrate binding domain and a C-terminal glycosyltransferase domain.
    1. Cell Biology
    2. Evolutionary Biology

    The wtf4 meiotic driver utilizes controlled protein aggregation to generate selective cell death

    Nicole L Nuckolls, Anthony C Mok ... Sarah E Zanders
    The Wtf4 antidote protein assembles with the Wtf4 poison protein and promotes the transportation of the assembled proteins to the vacuole for sequestration or destruction.
    1. Neuroscience

    Distinct hierarchical alterations of intrinsic neural timescales account for different manifestations of psychosis

    Kenneth Wengler, Andrew T Goldberg ... Guillermo Horga
    fMRI evidence for distinct hierarchical alterations in intrinsic neural timescales for different positive symptoms of schizophrenia support hierarchical perceptual-inference models of psychosis and suggest local increases in excitation-inhibition ratio.
    1. Medicine
    2. Neuroscience

    APOE2 is associated with longevity independent of Alzheimer’s disease

    Mitsuru Shinohara, Takahisa Kanekiyo ... Guojun Bu
    Translational evidence indicates APOE2 benefits longevity independent of its protective effects on Alzheimer’s disease, which preserved activity and the metabolism of apoE protein and associated-lipids would be key to understanding.
    1. Neuroscience

    Divergent projections of the prelimbic cortex bidirectionally regulate active avoidance

    Maria M Diehl, Jorge M Iravedra-Garcia ... Gregory J Quirk
    Projections from the prelimbic prefrontal cortex targeting the ventral striatum or the basolateral amygdala bidirectionally regulate platform-mediated active avoidance in rats.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Ebola and Marburg virus matrix layers are locally ordered assemblies of VP40 dimers

    William Wan, Mairi Clarke ... John AG Briggs
    Cryo-electron tomography reveals the structure and arrangement of the VP40 matrix protein lattice that mediates the formation of Ebola and Marburg virus particles.