Browse our latest research

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    1. Epidemiology and Global Health

    Differential occupational risks to healthcare workers from SARS-CoV-2 observed during a prospective observational study

    David W Eyre, Sheila F Lumley ... Timothy M Walker
    Risk factors for SARS-CoV-2 infection in healthcare workers included caring for Covid-19 patients, Black or Asian ethnicity, and Covid-19-positive household contacts, whereas a bundle of PPE-related measures protected ICU staff.
    1. Cancer Biology
    2. Cell Biology

    PARP1 inhibitors trigger innate immunity via PARP1 trapping-induced DNA damage response

    Chiho Kim, Xu-Dong Wang, Yonghao Yu
    Identification of PARP1 trapping as the major contributor of PARP1 inhibitor-induced innate immune response.
    1. Neuroscience

    Extensive and spatially variable within-cell-type heterogeneity across the basolateral amygdala

    Timothy P O'Leary, Kaitlin E Sullivan ... Mark S Cembrowski
    Basolateral amygdala excitatory neurons are a highly heterogenous collection of neurons that spatially covary in molecular, cellular, and circuit properties.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    EDF1 coordinates cellular responses to ribosome collisions

    Niladri K Sinha, Alban Ordureau ... Rachel Green
    Endothelial Differentiation Factor 1 (EDF1) plays a critical role in driving mRNA-specific quality control and global transcriptional responses in response to ribosome collisions.
    1. Ecology
    2. Physics of Living Systems

    Nutrient levels and trade-offs control diversity in a serial dilution ecosystem

    Amir Erez, Jaime G Lopez ... Ned S Wingreen
    Whereas theories of ecological diversity mostly consider continuously supplied nutrients, a seasonal model uncovers a general mechanism that controls diversity and reconciles conflicting experimental findings.
    1. Developmental Biology
    2. Neuroscience

    Alternative splicing at neuroligin site A regulates glycan interaction and synaptogenic activity

    Shinichiro Oku, Huijuan Feng ... Ann Marie Craig
    Inclusion of a neuroligin alternatively spliced insert that interacts with a neurexin glycan modification promote development of functional synaptic connections between neurons and may help alleviate consequences of NLGN mutations.
    1. Neuroscience

    Transformation of a temporal speech cue to a spatial neural code in human auditory cortex

    Neal P Fox, Matthew Leonard ... Edward F Chang
    The human brain has a spatial code for representing temporal phonetic distinctions in speech.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels

    Yiming Niu, Xiao Tao ... Roderick MacKinnon
    The structural role of PIP2 in opening the G-protein-gated K+ channel is revealed.
    1. Neuroscience

    Dissociable control of unconditioned responses and associative fear learning by parabrachial CGRP neurons

    Anna J Bowen, Jane Y Chen ... Richard D Palmiter
    Parabrachial neurons expressing CGRP relay affective components of ascending pain information via distinct thalamic and amygdalar pathways, which together contribute to complementary aspects of adaptive threat responses.
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Shadow enhancers can suppress input transcription factor noise through distinct regulatory logic

    Rachel Waymack, Alvaro Fletcher ... Zeba Wunderlich
    Proper development depends on establishing precise gene expression patterns in spite of the inherent noise in transcription, shadow enhancers buffer this noise by binding distinct input transcription factors.