Browse our Research Advances

Page 10 of 50
    1. Developmental Biology

    Comparative single-cell profiling reveals distinct cardiac resident macrophages essential for zebrafish heart regeneration

    Ke-Hsuan Wei, I-Ting Lin ... Shih-Lei (Ben) Lai
    An extensive characterization of inflammatory cell dynamics, function, and potential interaction during zebrafish cardiac repair identified specific resident macrophage subsets function in debris clearance, inflammatory resolution, and extracellular matrix remodeling, indispensable for successful heart regeneration.
    1. Neuroscience

    Nested circuits mediate the decision to vocalize

    Shuyun Xiao, Valerie Michael, Richard Mooney
    The decision to vocalize depends on neural circuits that balance the rewards of potential social affiliation with the risks of advertising.
    1. Neuroscience

    Inconsistencies between human and macaque lesion data can be resolved with a stimulus-computable model of the ventral visual stream

    Tyler Bonnen, Mark AG Eldridge
    A 'stimulus-computable' modeling approach resolves apparent inconsistencies between human and monkey lesion data, implicating perirhinal cortex in visual object perception.
    1. Structural Biology and Molecular Biophysics

    Structural and functional properties of the transporter SLC26A6 reveal mechanism of coupled anion exchange

    David N Tippett, Colum Breen ... Raimund Dutzler
    The structural and functional characterization of SLC26A6 provides greater understanding of coupled versus uncoupled transport processes for the SLC26 transporter family.
    1. Genetics and Genomics

    Expanding the stdpopsim species catalog, and lessons learned for realistic genome simulations

    M Elise Lauterbur, Maria Izabel A Cavassim ... Ilan Gronau
    Stdpopsim, a framework for generating realistic chromosome-scale simulations, is expanded to facilitate simulations for non-model species, resulting in insights into how such simulations should be designed.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

    Juan J Apiz Saab, Lindsey N Dzierozynski ... Alexander Muir
    Analysis of the tumor microenvironment reveals that pancreatic tumors experience metabolic stress caused by immune cell degradation of the amino acid arginine, and that pancreatic cancers cope by synthesizing arginine to provide access this amino acid despite low tumor availability.
    1. Neuroscience

    Development of frequency tuning shaped by spatial cue reliability in the barn owl’s auditory midbrain

    Keanu Shadron, José Luis Peña
    The juvenile barn owl displays wide heterogeneity in tuning properties in the auditory midbrain, which is shaped during development to match the pattern of sensory statistics experienced in early life and maintained into adulthood.
    1. Biochemistry and Chemical Biology
    2. Medicine

    Improved isolation of extracellular vesicles by removal of both free proteins and lipoproteins

    Dmitry Ter-Ovanesyan, Tal Gilboa ... David R Walt
    A novel immunoassay for ApoB-100, the main protein component of lipoproteins, enables the development of methods to enrich extracellular vesicles from human plasma while depleting both lipoproteins and free proteins.
    1. Cell Biology
    2. Computational and Systems Biology

    Transcriptional regulation of Sis1 promotes fitness but not feedback in the heat shock response

    Rania Garde, Abhyudai Singh ... David Pincus
    The chaperones Hsp70 and Sis1 collaborate to repress the heat shock response and are both transcriptional targets of the heat shock response, yet only Hsp70 acts as a negative feedback regulator of the heat shock response.
    1. Cancer Biology
    2. Cell Biology

    ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization

    Katarzyna Bogucka-Janczi, Gregory Harms ... Krishnaraj Rajalingam
    ERK3 controls actin cytoskeleton.