Early and late visual deprivation trigger a redeployment mechanism that reallocate part of the processing typically tagging the preserved senses (i.e. the temporal cortex for auditory stimulation) to the occipital cortex deprived of its most salient visual input.
Bronwyn A Lucas, Kexin Zhang ... Nikolaus Grigorieff
Comparing the relative similarity of cellular molecules to alternate templates allows classification of related complexes in the cell using fewer particles than needed for 3D classification and is more practicable for low abundance complexes.
Hierarchical transformations of visual representations, saccade-related activity, and sensorimotor associations occur in parallel at the juncture of visual and parietal cortex.
Structural and biochemical analysis of semisynthetic Akt forms and mutants has revealed the importance of a key interaction network involving Arg86, Glu17, and Tyr18 that controls Akt conformation and activity.
Prolonged β-adrenergic stimulation causes ryanodine receptor clusters to disperse, drastically altering the frequency and kinetics of Ca2+ release events called ‘Ca2+ sparks’ in a process that is dependent on CaMKII and PKA.
Deleting the first helix of the α-catenin actin-binding domain results in a slip bond interaction between the cadherin–catenin complex and F-actin, such that the binding interaction is stable at low force.
Jan Boelts, Jan-Matthis Lueckmann ... Jakob H Macke
A new machine learning method makes it possible to efficiently identify the parameters of cognitive models using Bayesian inference, even when only model simulations are available.
Allison T Goldstein, Terrence R Stanford, Emilio Salinas
The detection of a salient stimulus triggers a stereotypical oculomotor response, an impulse to look toward it, whose timing and strength are largely independent of behavioral significance and top-down control.
