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Inactivation of SURF4 leads to impaired secretion of PCSK9 and apolipoproteins resulting in low plasma cholesterol without detrimental consequences to the liver.

Parkinson’s disease-associated LRRK2 kinase is recruited to membranes by its Rab GTPase substrates, and LRRK2 is both retained on membranes and further activated there by cooperative interaction with the phosphorylated Rab proteins that it generates.

A light-controllable ligand is used to probe where in the signaling cascade T cells discriminate self from non-self.

A novel approach to studying anxiety reveals that learned anxiety and diazepam treatment have unique roles on prefrontal cortex and ventral tegmental area activity.

Somatic gonad architecture is regulated by innexin function, but sheath cell position does not determine germ cell exit from the stem cell pool.

By identifying cohesin's DNA entry gate(s) and through understanding the corresponding topology between the two the mechanism behind cohesin's activity is slowly deciphered and will aid in understanding how the SMC family at large functions.

As Caenorhabditis elegans adult hermaphrodite germ cells leave the stem cell niche, they associate with a pair of somatic gonad cells that were thought to be symmetrical, but that actually take on dramatically different positions in the organ.

Early and late visual deprivation trigger a redeployment mechanism that reallocate part of the processing typically tagging the preserved senses (i.e. the temporal cortex for auditory stimulation) to the occipital cortex deprived of its most salient visual input.

Comparing the relative similarity of cellular molecules to alternate templates allows classification of related complexes in the cell using fewer particles than needed for 3D classification and is more practicable for low abundance complexes.

Hierarchical transformations of visual representations, saccade-related activity, and sensorimotor associations occur in parallel at the juncture of visual and parietal cortex.