Browse our Research Articles

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    1. Structural Biology and Molecular Biophysics

    Specific Eph receptor-cytoplasmic effector signaling mediated by SAM–SAM domain interactions

    Yue Wang, Yuan Shang ... Mingjie Zhang
    Comparative structural studies reveal how the cytoplasmic tails of Eph receptors can differentiate different downstream target proteins via highly specific SAM–SAM domain interactions.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy

    Timothy F Miles, Katja Spiess ... K Christopher Garcia
    Numerous chemokine variants bearing no sequence resemblance elicit similar signaling behavior from the viral GPCR US28, suggesting a mechanism for receptor activation that accommodates extensive ligand degeneracy.
    1. Cancer Biology
    2. Immunology and Inflammation

    Tumor-derived CSF-1 induces the NKG2D ligand RAE-1δ on tumor-infiltrating macrophages

    Thornton W Thompson, Benjamin T Jackson ... David H Raulet
    Macrophages respond to elevated levels of CSF-1 in tumor micro-environments by expressing a ligand for the NKG2D immunoreceptor.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Epigenetic drift of H3K27me3 in aging links glycolysis to healthy longevity in Drosophila

    Zaijun Ma, Hui Wang ... Nan Liu
    Epigenetic drift of H3K27me3 is one of the molecular mechanisms that contribute to aging, and stimulation of glycolysis promotes metabolic health and longevity.
    1. Immunology and Inflammation

    Empty conformers of HLA-B preferentially bind CD8 and regulate CD8+ T cell function

    Jie Geng, John D Altman ... Malini Raghavan
    HLA-B*35:01 molecules that are peptide-deficient are thermostable, bind CD8 with higher affinity than their peptide-filled versions, accumulate at immunological synapses and enhance antigen-specific CD8+ T cell immune responses.
    1. Developmental Biology
    2. Immunology and Inflammation

    Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors

    Divyanshu Malhotra, Jimann Shin ... Erez Raz
    A new form of chemokine signaling bias that depends on cell state is identified.
    1. Structural Biology and Molecular Biophysics

    Oligomerization of a molecular chaperone modulates its activity

    Tomohide Saio, Soichiro Kawagoe ... Charalampos G Kalodimos
    A combined NMR and kinetic study demonstrates how the dynamic transition of a molecular chaperone between different oligomerization states can modulate its activity by altering the binding kinetics and energetics of non-native proteins.
    1. Computational and Systems Biology
    2. Plant Biology

    Coordination of robust single cell rhythms in the Arabidopsis circadian clock via spatial waves of gene expression

    Peter D Gould, Mirela Domijan ... James CW Locke
    Single cell analysis reveals how period differences between cells and cell-to-cell coupling generates the spatial structure of the plant circadian clock.
    1. Cancer Biology
    2. Developmental Biology

    PAX3-FOXO1 transgenic zebrafish models identify HES3 as a mediator of rhabdomyosarcoma tumorigenesis

    Genevieve C Kendall, Sarah Watson ... James F Amatruda
    The basic helix-loop-helix transcription factor, HES3, acts downstream of the PAX3-FOXO1 fusion oncogene to impair muscle differentiation and promote tumorigenesis in rhabdomyosarcoma, a childhood muscle cancer.
    1. Computational and Systems Biology
    2. Epidemiology and Global Health

    The intractable challenge of evaluating cattle vaccination as a control for bovine Tuberculosis

    Andrew James Kerr Conlan, Martin Vordermeier ... James LN Wood
    Natural transmission experiments should be prioritised over risky and expensive field trials, in order to establish the impact of cattle vaccination on the transmission of bovine Tuberculosis.