Aditya Mahadevan, Michael T Pearce, Daniel S Fisher
Evolution of multiple closely related strains with host-pathogen-like interactions but only one niche and no tradeoffs, can give rise to a spatiotemporally chaotic ecological state that continually diversifies even with generalist mutations that slow the evolution.
Contact tracing data reveal how a One Health approach underpinned by dog vaccination interrupts rabies transmission in reservoir populations removing the risk to humans, while virus genome data highlight the importance of surveillance and sustained dog vaccination in connected populations.
After domestication, the cultivation range expansion of crops was not solely dictated by human activity but instead constrained by climatic factors, which in turn resulted in distinct phenotypic characteristics of locally adaptive landraces.
HaDi MaBouDi, James AR Marshall ... Andrew B Barron
A fast and accurate decision-making strategy observed in bees, and reproduced in a neurally-grounded model, suggests a robust, risk-averse decision strategy suitable for when sampling and errors are both costly.
Guillem Torcal Garcia, Elisabeth Kowenz-Leutz ... Thomas Graf
A mutation in the lineage-determining regulator C/EBPα that increases the factor’s affinity for its partner PU.1 dramatically accelerates the velocity of B cell to macrophage transdifferentiation.
Ellen J Guss, Yulia Akbergenova ... J Troy Littleton
Loss of the extracellular matrix protein Perlecan leads to disruption of the neural lamella surrounding nerve bundles in Drosophila, resulting in axonal breakage and synaptic retraction of neuromuscular junctions.
Consuelo Ibar, Krishna Chinthalapudi ... Kenneth D Irvine
Insight into the activity of β-heavy spectrin is provided by the discovery that it can compete with myosin for association with F-actin, which provides explanations for its influences on Hippo signaling and morphogenesis.
Using unique data from five longitudinal UK birth cohorts, four distinct subsets of genetic variants were identified as differentially associated across wheezing phenotypes from infancy to adolescence with little evidence of genetic associations spanning across different phenotypes.
