Browse our Research Articles

Page 252 of 1,376
    1. Neuroscience

    Scn1a-GFP transgenic mouse revealed Nav1.1 expression in neocortical pyramidal tract projection neurons

    Tetsushi Yamagata, Ikuo Ogiwara ... Kazuhiro Yamakawa
    In neocortex, Nav1.1 is expressed in neocortical pyramidal tract projection neurons and a minor subpopulation of cortico-cortical projection neurons in addition to its predominant expression in inhibitory neurons, while the majority of cortico-thalamic, cortico-striatal, and cortico-cortical neurons express Nav1.2.
    1. Cell Biology
    2. Developmental Biology

    The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipose cell size

    Rupali Ugrankar-Banerjee, Son Tran ... W Mike Henne
    Fat-body-specific loss of actin isoform Act5C disrupts fat body cell growth and fat storage, lipoprotein secretion, and insulin signaling, revealing a non-canonical role for the cortical actin cytoskeleton in nutrient signaling and inter-organelle trafficking.
    1. Epidemiology and Global Health

    Nationwide participation in FIT-based colorectal cancer screening in Denmark during the COVID-19 pandemic: An observational study

    Tina Bech Olesen, Henry Jensen ... Morten Rasmussen
    The participation in the FIT-based colorectal cancer screening programme and subsequent compliance to colonoscopy after a positive FIT test was only slightly affected during the COVID-19 pandemic in Denmark.
    1. Cell Biology

    Endosomal trafficking of two-pore K+ efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury

    Long Shuang Huang, Mohammad Anas ... Asrar B Malik
    Rab11a-mediated endosomal trafficking in macrophages regulates potassium channel localization and activity at the cell surface and the downstream activation of the inflammasome and is a potential therapeutic target in acute or chronic inflammatory states.
    1. Cell Biology
    2. Developmental Biology

    The dark kinase STK32A regulates hair cell planar polarity opposite of EMX2 in the developing mouse inner ear

    Shihai Jia, Evan M Ratzan ... Michael R Deans
    The planar polarized organization of vestibular hair cells in the mouse inner ear is determined by the coordinated activities of the STK32A kinase and the transcription factor EMX2 to regulate the orphan receptor GPR156.
    1. Neuroscience

    Large-scale electrophysiology and deep learning reveal distorted neural signal dynamics after hearing loss

    Shievanie Sabesan, Andreas Fragner ... Nicholas A Lesica
    Deep neural network modeling of auditory processing identifies distorted cross-frequency interactions as the key problem for the processing of speech in noise after hearing loss.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Condensation of LINE-1 is critical for retrotransposition

    Srinjoy Sil, Sarah Keegan ... Liam J Holt
    The LINE-1 retrotransposon protein, ORF1p, forms a condensate on RNA that is essential for retrotransposition, and may explain cis-preference through a co-translational assembly mechanism.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    APE1 recruits ATRIP to ssDNA in an RPA-dependent and -independent manner to promote the ATR DNA damage response

    Yunfeng Lin, Jia Li ... Shan Yan
    Distinct interactions of AP endonuclease 1 with single-stranded DNA gaps and ATRIP and RPA protein complex address an outstanding question in the field of genome integrity regarding how ATR/ATRIP complex recruits onto damage site for ATR DNA damage response signaling.
    1. Medicine

    Biomedical supervisors’ role modeling of open science practices

    Tamarinde L Haven, Susan Abunijela, Nicole Hildebrand
    Supervisors' engagement in open science practices such as data sharing is associated with a greater odds that Ph.D. students engage in these practices and share their data.
    1. Neuroscience

    Synaptic and circuit mechanisms prevent detrimentally precise correlation in the developing mammalian visual system

    Ruben A Tikidji-Hamburyan, Gubbi Govindaiah ... Matthew T Colonnese
    The imprecise and broad connectivity of retinal inputs during development have the potential to generate large correlations in target neurons that reduce retinotopic information unless suppressed by the special synaptic and circuit properties present at these ages.