Browse our Research Articles

Page 412 of 1,377
    1. Evolutionary Biology

    A meta-analysis of the association between male dimorphism and fitness outcomes in humans

    Linda H Lidborg, Catharine Penelope Cross, Lynda G Boothroyd
    While men’s mating success is predicted both by their strength/muscularity, voice pitch, height, and testosterone levels, their reproductive output is only predicted by strength/muscularity.
    1. Computational and Systems Biology
    2. Developmental Biology

    Efficient differentiation of human primordial germ cells through geometric control reveals a key role for Nodal signaling

    Kyoung Jo, Seth Teague ... Idse Heemskerk
    Highly reproducible and efficient human primordial germ cell differentiation was achieved through geometric confinement, which enabled quantitative dissection of the cell signaling driving this differentiation, revealing a major role of Wnt signaling is indirect by inducing Nodal signaling.
    1. Neuroscience

    Early detection of cerebrovascular pathology and protective antiviral immunity by MRI

    Li Liu, Steve Dodd ... Alan P Koretsky
    A MRI study of virally infected CNS demonstrates the utility of MRI in detecting the earliest pathological events and studying pathogen-specific T cells at the level of single cell as well as the therapeutic potential of antiviral T cells.
    1. Neuroscience

    Dopaminergic regulation of vestibulo-cerebellar circuits through unipolar brush cells

    Jose Ernesto Canton-Josh, Joanna Qin ... Yevgenia Kozorovitskiy
    For cerebellar unipolar brush cells that regulate information flow to the vestibulo-cerebellum, dopaminergic modulation by locus coeruleus axons presents a new example of monoaminergic co-release poised to regulate the activity of the cerebellar cortex.
    1. Neuroscience

    Anatomical and functional connectivity support the existence of a salience network node within the caudal ventrolateral prefrontal cortex

    Lucas R Trambaiolli, Xiaolong Peng ... Suzanne N Haber
    The primate caudal area 47/12 is anatomically and functionally connected with the main nodes of the salience network, supporting the role of the ventrolateral prefrontal cortex in all major attention networks.
    1. Neuroscience

    Invariant neural subspaces maintained by feedback modulation

    Laura B Naumann, Joram Keijser, Henning Sprekeler
    Feedback-driven gain modulation provides a mechanism to generate and maintain invariant sensory representations in the presence of contextual changes by dynamically adapting feedforward sensory processing.
    1. Neuroscience

    Auditory mismatch responses are differentially sensitive to changes in muscarinic acetylcholine versus dopamine receptor function

    Lilian Aline Weber, Sara Tomiello ... Klaas Enno Stephan
    Biperiden, but not amisulpride, delays auditory mismatch responses during environmental stability, suggesting a differential sensitivity of auditory statistical learning to muscarinic versus dopaminergic receptor status which could prove useful for developing tests that predict an individual's response to antipsychotic treatment.
    1. Cell Biology
    2. Physics of Living Systems

    Zebrafish airinemes optimize their shape between ballistic and diffusive search

    Sohyeon Park, Hyunjoong Kim ... Jun Allard
    Mathematical characterization of the shape of cellular protrusions that form cell–cell contacts in tissues reveals the parameters required for optimizing biological functional objectives, like maximizing cell–cell contact and communicating directional information.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Microevolution of Trypanosoma cruzi reveals hybridization and clonal mechanisms driving rapid genome diversification

    Gabriel Machado Matos, Michael D Lewis ... Björn Andersson
    Unique mechanisms of genetic exchange in the important protozoan pathogen Trypanosome cruzi were characterized in detail using genome analyses of hybrid clones at different time points, showing initial tetraploids followed by genome erosion.
    1. Genetics and Genomics
    2. Neuroscience

    Reorganization of postmitotic neuronal chromatin accessibility for maturation of serotonergic identity

    Xinrui L Zhang, William C Spencer ... Evan S Deneris
    Terminal selectors reorganize postmitotic neuronal chromatin to select cis-regulatory elements during 5-HT neuron maturation.