Browse our Research Articles

The RNA helicase DDX3X controls neural progenitor division, cell fate, and translation during embryonic brain development.

The dominant MRSA circulating in European livestock has stably maintained genes associated with resistance to antibiotic treatments over several decades and when it is transmitted to humans it can rapidly acquire genes that allow it to evade human immune responses.

Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.

Robotic AI system automated discovery of optimum cell culture protocol, a most experience-dependent process in regenerative medicine.

A novel model is presented that reconciles in-cell structure probing data with splicing regulatory elements to predict exon 10 inclusion of the Tau gene with high accuracy for 53 splice altering mutations.

Cytotoxic CD4 T lymphocytes are abundantly generated in T. cruzi-infected mice, predominantly infiltrate infected hearts, depend on T-cell intrinsic IL-18R/MyD88 signaling for expansion and their blood frequency correlates with the severity of chronic myocarditis in patients with Chagas disease.

The mechanistic origins of distinct brain malformations associated with different substitutions at α-tubulin residue 409 are examined, revealing disruption of neuronal migration and microtubule regulation by XMAP215 that scales from protein to tissue.

A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.

Cystathionine-β-synthase is a novel metabolic regulator of AKT-induced senescence and a potential tumor suppressor in gastric cancer pathogenesis which can be harnessed to target PI3K/AKT-driven cancers.

Genome-wide CRISPR screens in human cells identifies a role for TRIM37 in growth arrest after chemical inhibition of PLK4.