Fungi that produce mushrooms have a unique life cycle with two haploid nuclei, instead of a diploid nucleus, this allows additional matings and selection at the level of the nucleus, even with a fitness trade-off.
A streamlined form of the bacterial System I cytochrome c biogenesis machinery in archaea was characterized using Methanosarcina acetivorans as a model system.
Chi-Hong Wu, Vedakumar Tatavarty ... Gina G Turrigiano
Activity-dependent bidirectional changes in phosphorylation of the autism-associated scaffold protein Shank3 are essential for the expression of homeostatic synaptic plasticity.
Robert Warneford-Thomson, Parisha P Shah ... Roberto Bonasio
COV-ID is a highly scalable technology that utilizes a two-step barcoding strategy to detect viral RNAs in saliva samples combining RT-LAMP, PCR, and next generation sequencing.
Andrea Toledo, Mathieu Letellier ... Olivier Thoumine
MDGAs are highly diffusive molecules that alter both neuroligin-1 and AMPA receptor dynamics and function, thereby significantly delaying the differentiation of excitatory post-synapses.
Klaus Bonazza, Roxana E Iacob ... Timothy A Springer
Both the polypeptide and attached O-glycans N-terminal to the A1 domain in von Willebrand factor lower its affinity for its ligand GPIbα on platelets, its stability, and structural dynamics and decrease population of a high-affinity, intermediate state in unfolding.
Oxytocin neurons in the paraventricular nucleus of the hypothalamus mediate the increased sociability as a consequence of acute social isolation during adolescence via ventral tegmental area circuits.
The transformation of multiple streams of sensory information into an estimate of body motion occurs between the cerebellum and deep cerebellar nucleus to ensure postural and perceptual stability.
