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Infrared high-pulse-energy low-pulse-repetition-rate excitation advances deep intravital microscopy in strongly scattering tissues such as skin tumors and thick bone, thereby bringing previously inaccessible tumor areas in reach with subcellular resolution.

The repression of HIF-1 plays a central role in mitochondrial reactive oxygen species (ROS) overproduction and subsequent tissue damage in diabetes, which is mediated by increased mitochondrial respiration, making HIF-1 signaling an attractive therapeutic target for diabetes complications.

Mer2 interacts directly with meiotic chromatin, axial proteins, and the DNA break forming machinery to facilitate the formation of meiotic double-strand breaks.

A functional connectivity gradient in striatum is obtained that maps onto DaT SPECT-derived dopaminergic projections and thereby likely provides a new biomarker for investigating dopaminergic (dys)function in the human brain.

A multiomics, systems biology approach was used to define the metabolic and signaling programs that drive the fate and function of pancreatic tumor-associated macrophages.

Long-term chemogenetic manipulation of specific cerebellar pathway involving ventral tegmental area revealed a critical role of the pathway as a proactive mediator of the stress-dependent development of depression-like behaviors.

A one-photon three-dimensional light sculpture technique has been developed and demonstrated for high spatio-temporal resolution photostimulation and imaging of dozens of neurons in the intact mouse brain in vivo.

Attention-grabbing tasks produce rapid opioid-mediated analgesia via the descending pain modulation network to alter spinal neuronal activity.

Topoisomerase VI selectively catalyzes strand passage of DNA molecules juxtaposed at close to a right angle, which explains the observed chiral-dependent activity and preferential DNA decatenation versus supercoil relaxation.

Exceptionally preserved small shelly fossils (SSFs) from the early Cambrian Kuanchuanpu Formation (535 million years ago) reveal the muscular system of ancient cnidarians.