Browse our Research Articles

Page 521 of 1,471
    1. Computational and Systems Biology

    Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice

    Zhenghao Chen, Anil Raj ... Adam Freund
    A non-invasive animal monitoring system paired with a custom analysis pipeline allows organism-level aging to be studied with improved throughput, resolution, and physiological scope while reducing the activation energy that comes with highly specialized challenge-based procedures.
    1. Ecology
    2. Microbiology and Infectious Disease

    Competition for fluctuating resources reproduces statistics of species abundance over time across wide-ranging microbiotas

    Po-Yi Ho, Benjamin H Good, Kerwyn Casey Huang
    A simple model provides an accessible framework to infer macroscopic parameters of effective resource competition from longitudinal studies of microbial communities.
    1. Neuroscience

    Young domestic chicks spontaneously represent the absence of objects

    Eszter Szabó, Cinzia Chiandetti ... Giorgio Vallortigara
    Without specific training, young chicks represent the absence of objects, showing that the concept of 'nothing' is available to nonhuman animals and does not require linguistic tools, such as negation.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Co-aggregation and secondary nucleation in the life cycle of human prolactin/galanin functional amyloids

    Debdeep Chatterjee, Reeba S Jacob ... Samir K Maji
    Co-aggregation, amyloid formation, and unidirectional cross-seeding of prolactin and galanin for their efficient storage in secretory granules of pituitary and subsequent functional hormone release.
    1. Microbiology and Infectious Disease

    Impact of a human gut microbe on Vibrio cholerae host colonization through biofilm enhancement

    Kelsey Barrasso, Denise Chac ... Wai-Leung Ng
    A specific gut microbe Paracoccus aminovorans enhances host colonization of the human pathogen Vibrio cholerae by forming dual-species biofilm structures.
    1. Medicine

    Novel protein markers of androgen activity in humans: proteomic study of plasma from young chemically castrated men

    Aleksander Giwercman, K Barbara Sahlin ... Johan Malm
    Three new protein markers of testosterone action identified by us, may prove to be valuable as clinical tools in identifying men with testosterone deficiency and in monitoring androgen replacement therapy.
    1. Developmental Biology

    Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling

    Dina Rekler, Chaya Kalcheim
    BMP-dependent retinoic acid signaling is responsible for the separation of central from peripheral lineages during neural development.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Agl24 is an ancient archaeal homolog of the eukaryotic N-glycan chitobiose synthesis enzymes

    Benjamin H Meyer, Panagiotis S Adam ... Helge C Dorfmueller
    The crenarchaeon Sulfolobus synthesizes the N-glycan core in the identical way as all Eukaryotes, which strengthens the hypothesis that the eukaryotic N-glycosylation is acquired from an ancient archaeon during eukaryogenesis.
    1. Neuroscience

    Schema representations in distinct brain networks support narrative memory during encoding and retrieval

    Rolando Masís-Obando, Kenneth A Norman, Christopher Baldassano
    Neural representations of both general event schemas and story-specific details predict memory performance in narrative recall, with distinct brain networks tracking schematic information during perception versus retrieval.
    1. Medicine

    A novel immunopeptidomic-based pipeline for the generation of personalized oncolytic cancer vaccines

    Sara Feola, Jacopo Chiaro ... Vincenzo Cerullo
    An immunopeptidomic-based pipeline provides a tool for the identification of cancer therapeutic targets and generation of cancer oncolytic vaccines.