Browse our Research Articles

Combining ribosome profiling and RNA sequencing illuminates novel features of porcine reproductive and respiratory syndrome virus gene expression, including the regulation of polyprotein stoichiometry through temporal modulation of ribosomal frameshifting and the synthesis of non-canonical transcripts.

A neural network showed better prediction of upcoming states when it was selective in when it encoded and retrieved episodic memories, thereby explaining why humans show this selectivity in studies of naturalistic memory.

Mapping spike patterns from a small identified circuit reveals the diversity and complexity of circuit dynamics across animals and in response to perturbations.

In the bacterial small multidrug transporter EmrE, sidechain rearrangements in the binding site accommodate structurally diverse substrates without major rearrangements of the protein backbone.

The immunoglobulin superfamily cell surface protein Sticks and Stones is a binding partner for the Lar Drosophila receptor tyrosine phosphatase that mediates Lar's developmental functions at the larval neuromuscular junction, mushroom body, and adult optic lobe.

Multicellular systems exhibiting a wide variety of behaviors, including logic gates, band-pass filtering, and bistability, are constructed from a fixed vocabulary of input-output strains through model-guided design demonstrating predictable composability, tunability, and extendability.

Multiple cryo-electron microscopy structures of a plant ABC transporter exporting glutathione derivatives captured a closed conformation proposed to enforce the export directionality, while a complex central to the coupling mechanism containing both glutathione and closed nucleotide binding domains remains elusive.

The fate of duplicated transcription factors within budding yeast is described, providing insights into the mechanisms that shape transcriptional networks during evolution.

A novel mechanism by which a compartment-specific AAA+ complex mediating organelle biogenesis and protein quality control staves off induction of selective autophagy.

Primordial cyanobacterial PSI structure.