Browse our Research Articles

Page 522 of 1,471
    1. Neuroscience

    The enteric nervous system of the C. elegans pharynx is specified by the Sine oculis-like homeobox gene ceh-34

    Berta Vidal, Burcu Gulez ... Oliver Hobert
    Genetic analysis reveals the molecular logic of specifying and maintaining the enteric nervous system of the nematode Caenorhabditis elegans.
    1. Microbiology and Infectious Disease

    Inhibiting host-protein deposition on urinary catheters reduces associated urinary tract infections

    Marissa Jeme Andersen, ChunKi Fong ... Ana L Flores-Mireles
    The use of liquid-infused catheters results in significant reduction of bladder and catheter colonization, systemic dissemination, and bladder inflammation in a clinically relevant mouse model of CAUTI by targeting host-protein deposition on the urinary catheter.
    1. Physics of Living Systems

    How to assemble a scale-invariant gradient

    Arnab Datta, Sagnik Ghosh, Jane Kondev
    Intracellular protein gradients, which are formed by the combined action of cytoplasmic diffusion and cortical transport toward the cell pole, are solely determined by cell shape.
    1. Neuroscience

    Minimal requirements for a neuron to coregulate many properties and the implications for ion channel correlations and robustness

    Jane Yang, Husain Shakil ... Steven A Prescott
    In order to homeostatically regulate many (n) properties at the same time, neurons must coadjust many (n + 1) ion channels with the appropriate ratios, which can lead to ion channel correlations and increased risk of regulation failure.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Glypican-1 drives unconventional secretion of fibroblast growth factor 2

    Carola Sparn, Eleni Dimou ... Walter Nickel
    Identification of a heparan sulfate proteoglycan with a dedicated function in unconventional protein secretion reveals an intimate relationship between fibroblast growth factor 2 and Glypican-1 in cancer biology.
    1. Ecology

    Mammals adjust diel activity across gradients of urbanization

    Travis Gallo, Mason Fidino ... Seth B Magle
    Mammals use time along the 24-hr cycle to reduce risk, adapt, and therefore persist in urban ecosystems.
    1. Evolutionary Biology

    Late-life fitness gains and reproductive death in Cardiocondyla obscurior ants

    Luisa Maria Jaimes-Nino, Jürgen Heinze, Jan Oettler
    Lifelong continuous reproduction, late-life investment into female sexuals, a short phase of senescence, and reproductive death characterize the life history of Cardiocondyla obscurior ant queens.
    1. Cell Biology
    2. Developmental Biology

    Actin-related protein 5 functions as a novel modulator of MyoD and MyoG in skeletal muscle and in rhabdomyosarcoma

    Tsuyoshi Morita, Ken'ichiro Hayashi
    Actin-related protein 5 antagonizes the interaction of Pbx/Meis with myogenic regulatory factors such as MyoD and MyoG, which is involved in the recruitment of the BRG1-based switch/sucrose nonfermentable chromatin remodeling complex required for myogenic gene activation.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    SARS-CoV2 variant-specific replicating RNA vaccines protect from disease following challenge with heterologous variants of concern

    David W Hawman, Kimberly Meade-White ... Jesse H Erasmus
    A replicating RNA vaccine platform generated significant immunity against SARS-CoV2 in mice and hamsters, and can be updated to target variants of concern.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Quantification of protein abundance and interaction defines a mechanism for operation of the circadian clock

    Alex A Koch, James S Bagnall ... Andrew SI Loudon
    Dynamic interactions of core clock molecules are quantitively measured and mathematically modelled to reveal the hidden role of PER:CRY complexes in enhancing the mobility of CLOCK:BMAL1 to move to new DNA sites.