Yeast bromodomain-containing factors Bdf1/2 offer insights into the biological role of the BET family of transcriptional regulators, which is a promising target in cancer therapy.
Markus Pfenninger, Friederike Reuss ... Barbara Feldmeyer
European beech harbours substantial genetic variation at genomic loci associated with drought resistance and newly identified loci can help to accelerate and monitor adaptation to climate change.
Haritha Mathsyaraja, Jonathen Catchpole ... Robert N Eisenman
The MYC transcription factor network member MGA is a subunit of a non-canonical Polycomb complex, which, when inactivated, accelerates tumorigenesis in mouse models of cancer and proliferation in colon organoids.
Timothy M Wolock, Seth Flaxman ... Jeffrey W Eaton
Integrating the sinh-arcsinh distribution into a distributional regression framework allows us to produce precise, local estimates of sexual age-mixing, facilitating more accurate modelling of sexually transmitted disease dynamics.
Routine and campaign vaccination disruption in 2020 may lead to measles outbreaks and yellow fever burden increases in some countries, but is unlikely to greatly increase meningococcal A burden.
Zachary K Barth, Maria HT Nguyen, Kimberley D Seed
Horizontal transfer of a sequence-specific DNA-binding domain allows a virus to destroy its subviral parasite and overcome parasite-mediated restriction.
The upper airway commensal, Neisseria cinerea, competes with related species using a T6SS, with antagonism modulated by the spatial dynamics of attacker and prey strains growing in a mixed community.
Elektra K Robinson, Pratibha Jagannatha ... Susan Carpenter
Alternative first exon usage was the major event observed in macrophages during inflammation, which resulted in the elucidation of a novel isoform and regulatory mechanism of the protein-coding gene, Aim2.
