Browse our Research Articles

Page 615 of 1,477
    1. Neuroscience

    Circadian regulation of vertebrate cone photoreceptor function

    Jingjing Zang, Matthias Gesemann ... Stephan CF Neuhauss
    Circadian expression of cone visual transduction genes and corresponding proteins correlates with circadian changes in photoresponse kinetics and visual behavior, linking circadian gene expression with physiological and behavioral rhythmicity.
    1. Cell Biology
    2. Neuroscience

    Activity-dependent Golgi satellite formation in dendrites reshapes the neuronal surface glycoproteome

    Anitha P Govind, Okunola Jeyifous ... William N Green
    Neuronal activity triggers the dispersal of the Golgi into dendritic Golgi satellites, leading to reshaping of the neuronal surface glycoproteome through processing of glycans to mature, sialic acid-containing forms.
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Multiple introductions of multidrug-resistant typhoid associated with acute infection and asymptomatic carriage, Kenya

    Samuel Kariuki, Zoe A Dyson ... Gordon Dougan
    Carriage of MDR S. Typhi H58 sublineages that also cause acute disease provides understanding of the transmission dynamics of typhoid fever and maintenance of local pathogen populations in Kenya children.
    1. Neuroscience

    Calcium dependence of neurotransmitter release at a high fidelity synapse

    Abdelmoneim Eshra, Hartmut Schmidt ... Stefan Hallermann
    The Ca2+-dependence of vesicle priming, fusion, and replenishment at cerebellar mossy fiber boutons show a prominent Ca2+-dependent priming step, a shallow non-saturating dose-response curve up to 50 µM, and little Ca2+-dependence of sustained vesicle replenishment.
    1. Developmental Biology

    End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

    Richard Venz, Tina Pekec ... Collin Yvès Ewald
    Inducible degradation of the insulin/insulin-like growth factor-1 receptor shows that a doubling in lifespan is possible even at extremely old ages in an organism.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Variation in human herpesvirus 6B telomeric integration, excision, and transmission between tissues and individuals

    Michael L Wood, Colin D Veal ... Nicola J Royle
    Human herpesvirus 6B can transition between telomere-integrated and free viral forms, and frequent telomere-loop-driven partial or complete viral genome excision events create mosaicism in germline carriers of inherited chromosomally integrated HHV-6B.
    1. Cell Biology

    Ectocytosis prevents accumulation of ciliary cargo in C. elegans sensory neurons

    Adria Razzauti, Patrick Laurent
    Disposal of ciliary proteins via ectosomes budding from cilia tip or cilia base acts as a safeguard mechanism when cilia trafficking functions are impaired.
    1. Neuroscience

    Modeling spinal locomotor circuits for movements in developing zebrafish

    Yann Roussel, Stephanie F Gaudreau ... Tuan V Bui
    Computational models of spinal locomotor circuits in developing zebrafish reveal how new movements can emerge during development through the integration of new spinal neurons and new connections.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Local adaptation and archaic introgression shape global diversity at human structural variant loci

    Stephanie M Yan, Rachel M Sherman ... Rajiv C McCoy
    Graph genotyping of structural variation in diverse human populations reveals functional associations and signatures of local adaptation within poorly resolved regions of the genome.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Information content differentiates enhancers from silencers in mouse photoreceptors

    Ryan Z Friedman, David M Granas ... Michael A White
    Silencers and enhancers targeted by a common transcription factor in photoreceptors are distinguished by the number and diversity of binding transcription factor binding sites they contain.