Browse our Research Articles

Page 616 of 1,392
    1. Computational and Systems Biology
    2. Neuroscience

    Action detection using a neural network elucidates the genetics of mouse grooming behavior

    Brian Q Geuther, Asaf Peer ... Vivek Kumar
    A machine learning method for action detection is developed and applied toward mouse grooming behavior.
    1. Biochemistry and Chemical Biology

    Mapping the functional landscape of the receptor binding domain of T7 bacteriophage by deep mutational scanning

    Phil Huss, Anthony Meger ... Srivatsan Raman
    An unbiased mutational screen decodes the molecular basis of phage receptor interactions, identifies key functional regions determining activity and host range, and demonstrates the potential for engineering therapeutic phages.
    1. Chromosomes and Gene Expression
    2. Medicine

    Cardiovascular disease risk factors induce mesenchymal features and senescence in mouse cardiac endothelial cells

    Karthik Amudhala Hemanthakumar, Shentong Fang ... Riikka Kivelä
    Endothelial dysfunction due to cardiovascular disease risk factors explained by cardiac endothelial cell transcriptome remodelling.
    1. Ecology

    Relative demographic susceptibility does not explain the extinction chronology of Sahul’s megafauna

    Corey JA Bradshaw, Christopher N Johnson ... Frédérik Saltré
    There is no relationship between the demographic susceptibility to extinction and the estimated extinction chronology among Sahul’s megafauna, suggesting that human choices, a species’ ecological requirements, and/or random climate variation instead determined the extinction chronology.
    1. Genetics and Genomics

    Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement

    Astrid Hoermann, Sofia Tapanelli ... Nikolai Windbichler
    Minimal genetic modifications of endogenous mosquito genes allow the tissue-specific expression of anti-malarial effectors and convert them into efficient non-autonomous gene drives.
    1. Cell Biology

    A genetic screen identifies new steps in oocyte maturation that enhance proteostasis in the immortal germ lineage

    Madhuja Samaddar, Jérôme Goudeau ... Cynthia Kenyon
    A whole-genome genetic screen links new aspects of oocyte maturation to proteostasis renewal in the immortal Caenorhabditis elegans germ-cell lineage and reveals similarities to somatic cell maintenance during aging.
    1. Immunology and Inflammation
    2. Neuroscience

    Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition

    Alessio Vittorio Colombo, Rebecca Katie Sadler ... Arthur Liesz
    Experiments in a mouse model for Alzheimer’s disease using germ-free and conventionally housed animals reveal that microbiota-derived short-chain fatty acids promote the deposition of cerebral Aβ plaques.
    1. Developmental Biology
    2. Genetics and Genomics

    Cell competition removes segmental aneuploid cells from Drosophila imaginal disc-derived tissues based on ribosomal protein gene dose

    Zhejun Ji, Jacky Chuen ... Nicholas Baker
    Cell competition is an important mechanism selecting against aneuploid cells.
    1. Microbiology and Infectious Disease

    Infection with a newly designed dual fluorescent reporter HIV-1 effectively identifies latently infected CD4+ T cells

    Jinfeng Cai, Hongbo Gao ... Kai Deng
    A novel reporter model system serves as a valuable tool for studying latent HIV-1 infection and identifies potent latency reversing agent.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Human cytomegalovirus antagonizes activation of Fcγ receptors by distinct and synergizing modes of IgG manipulation

    Philipp Kolb, Katja Hoffmann ... Hartmut Hengel
    Molecular mechanisms reveal that human cytomegalovirus has evolved to deploy two individual glycoproteins working in synergy to efficiently evade antibody-mediated immunity mediated by Fc-gamma receptors.